Results 71 to 80 of about 615,135 (283)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Expansion planning studies of generation sector in highly renewable energy systems considering flexibility requirements

International Journal of Electrical Power & Energy Systems
This work focuses on the development of a decarbonization-based generation expansion planning (GEP) model taking into account short-term operational constraints.
Kianoosh Choubineh, Hossein Yousefi, Moein Moeini-Aghtaie   +2 more
doaj   +1 more source

An Analytical Approach For Transmission Expansion Planning with Generation Variations

Transactions on Environment and Electrical Engineering, 2017
Planning for expanding a power system under different scenarios is one of the major challenge for power engineers hence, it is very important and essential to implement a well-balanced and feasible system over a time horizon under suitable assumptions ...
Maneesh Kumar, Raminder Kaur
doaj   +1 more source

A reliability based model for generation and transmission expansion planning [PDF]

, 2016
This paper presents a mixed integer linear multi-objective model based on information gap decision theory (IGDT), which is used to solve coordinated multiyear generation and transmission expansion planning (G&TEP) problems.
Ahmadi, A, Mavalizadeh, H, Shayanfar, HA, Zobaa, AF   +3 more
core  

Composite generation and transmission expansion planning considering distributed generation

International Journal of Electrical Power & Energy Systems, 2014
Abstract This paper presents a model for use in the problem of composite generation and transmission expansion planning considering distributed generation. Generation expansion planning is defined as the problem of determining what capacity, which, and when new generating units should be constructed over a long range planning horizon, to satisfy the ...
Ahmad Rouhani, Seyyed Hadi Hosseini, Mahdi Raoofat   +2 more
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Accelerating the Composite Power System Planning by Benders Decomposition [PDF]

Journal of Operation and Automation in Power Engineering, 2014
This paper presents an application of Benders decomposition to deal with the complexities in the simultaneous Generation Expansion Planning (GEP) and Transmission Expansion Planning (TEP).
Behnam Alizadeh, Shahram Jadid
doaj  

Generation and Transmission Expansion Planning with Full-year Hourly Power Balance [PDF]

Brazilian Archives of Biology and Technology
Variable renewable energies are leading the energy transition and power system flexibility has become a global priority. Incorporating short-term assessment into long-term planning is essential to capture the operational characteristics of generation and
Thiago José da Luz, Clodomiro Unsihuay-Vila   +1 more
doaj   +1 more source

Linear Optimal Power Flow Using Cycle Flows

, 2018
Linear optimal power flow (LOPF) algorithms use a linearization of the alternating current (AC) load flow equations to optimize generator dispatch in a network subject to the loading constraints of the network branches.
Brown, Tom, Hörsch, Jonas, Ronellenfitsch, Henrik, Witthaut, Dirk   +3 more
core   +1 more source