Results 91 to 100 of about 1,461,187 (297)

Enumeration of distinct mechanically stable disk packings in small systems

open access: yes, 2006
We create mechanically stable (MS) packings of bidisperse disks using an algorithm in which we successively grow or shrink soft repulsive disks followed by energy minimization until the overlaps are vanishingly small.
Adam G   +21 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

A practical generation-interval-based approach to inferring the strength of epidemics from their speed

open access: yesEpidemics, 2019
Infectious disease outbreaks are often characterized by the reproduction number R and exponential rate of growth r. R provides information about outbreak control and predicted final size, but estimating R is difficult, while r can often be estimated ...
Sang Woo Park   +3 more
doaj   +1 more source

Evaluation of domestic electrical demand and its effect on low voltage network performance [PDF]

open access: yes, 2012
Electrical demand in a house depends on various factors mainly being the user’s behaviour and the rating of the appliances. Some researchers have used daily domestic electrical demand profile at half hour time resolution for the energy management.
Karmacharya, Samir   +3 more
core  

The Near Infrared Background: Interplanetary Dust or Primordial Stars?

open access: yes, 2005
The intensity of the diffuse ~ 1 - 4 micron sky emission from which solar system and Galactic foregrounds have been subtracted is in excess of that expected from energy released by galaxies and stars that formed during the z < 5 redshift interval (Arendt
Eli Dwek   +5 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Inferring the differences in incubation-period and generation-interval distributions of the Delta and Omicron variants of SARS-CoV-2. [PDF]

open access: yesProc Natl Acad Sci U S A, 2023
Park SW   +11 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Generation of an Interval Metric Scale to Measure Attitude

open access: yesSAGE Open, 2014
This article discusses issues of scales in measuring attitude, demonstrates how a metric scale can be generated based on three main features, and presents results from a repeated measurement survey to verify the generated scale.
Rohana Yusoff, Roziah Mohd Janor
doaj   +1 more source

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