Results 181 to 190 of about 3,630,229 (221)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source
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Generating chaos via x|x|

IEEE Transactions on Circuits and Systems I: Fundamental Theory and Applications, 2001
Here, the authors discuss the existence of chaos for the following Duffing-like oscillator \[ \ddot x-ax +bx|x|=\varepsilon (-\zeta \dot x +c\sin (\omega t)) \] by using the Melnikov-function method. It is shown that the piecewise quadraticfunction \(x|x|\) can be seen as a chaos generator. Its physcial meaning as an energy function is explained.
Tang, Kit-Sang   +3 more
openaire   +2 more sources

Generation X

This encyclopedia provides a comprehensive and nuanced exploration of Generation X and its enduring imprint on the cultural landscape of the USA, in realms such as music, television, literature, advertising, and art. American life has changed significantly in the last 70 years.
Kevin L. Ferguson, Melissa Lenos
openaire   +2 more sources

Understanding Generation X Employees

JONA: The Journal of Nursing Administration, 1998
Understanding Generation X employees--those born between 1961 and 1981--is essential if they are to be recruited into and retained in nursing and their potential maximized. The author discusses the times, characteristics, and work values and demands of Generation X.
openaire   +2 more sources

Generalized X-code

ACM Transactions on Storage, 2012
Many RAID-6 codes have been proposed in the literature, but each has its limitations. Horizontal code has the ability to adapt to the arbitrary size of a disk array but its high computational complexity is a major shortcoming. In contrast, the computational complexity of vertical code (e.g.
Xianghong Luo, Jiwu Shu
openaire   +1 more source

Generation X-pendable

Journal of Sociology, 2009
Many small communities across the vast interior of Australia are under pressure from ongoing rural restructuring and a long-running drought. Socioeconomic indicators suggest that rural people are significantly disadvantaged by comparison with their urban counterparts. While these factors are evident, less well understood are the circumstances of rural
Margaret Alston, Jenny Kent
openaire   +1 more source

Generation X women

2008
Generation X women exhibit specific secondary characteristics in addition to the primary characteristics all women possess. Generation X women are independent and more conventional in their attitudes. They try to balance traditional and modern lifestyles. They have a strong sense of responsibility and are often described as part of the “Lost Generation.
Iain Ellwood, Sheila Shekar
openaire   +1 more source

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