Results 141 to 150 of about 24,622,115 (294)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Design and Safety Studies of the Molten Salt Fast Reactor Concept in the Frame of the SAMOFAR H2020 Project

, 2018
Since more than 15 years, the National Centre for Scientific Research (CNRS, France) has focused R&D efforts on the development of a new molten salt reactor concept called the Molten Salt Fast Reactor (MSFR) selected by the Generation-IV International ...
Carluec B., Delpech S., Gerber A., Lorenzi S., Rineiski A., Uggenti A. C., Tiberi V., Carpignano A., Merle E., Di Ronco A., Massone M., Gerardin D., Heuer D., Laureau A., Beils S., Flauw Y., Cammi A., Dulla S., Allibert A.   +18 more
core  

Comment on: "Millennials in Psychiatry: Exploring Career Choice Factors in Generation Y Psychiatry Interns". [PDF]

Acad Psychiatry, 2020
Sharma RK.
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Estudio de factibilidad del "plan nacional de innovación, ciencia y tecnología-plan ICT". [PDF]

, 2013
Este Resumen Ejecutivo contiene los principales hallazgos obtenidos en el marco del diagnóstico realizado y presentado en el segundo informe. Asimismo se completa con la descripción general de las propuestas finales presentadas y validadas en el cuarto ...
Consejo Nacional de Ciencia y Tecnología (CONACYT)
core  

RGB generation in secondary cores of microstructured fibres

Generation of white laser light in the visible regime currently attracts a lot of attention. Optical-fibre-based solutions have so far been presented by supercontinuum generation in tapered fibres and small-core microstructured holey fibres.
Petrovich, M.N., Horak, P., Jeong, Y., Nilsson, J., Dupriez, P., Richardson, D.J., Poletti, F., Payne, D.N.   +7 more
core   +1 more source

Are gamers better laparoscopic surgeons? Impact of gaming skills on laparoscopic performance in "Generation Y" students. [PDF]

PLoS One, 2020
Datta R, Chon SH, Dratsch T, Timmermann F, Müller L, Plum PS, Haneder S, Pinto Dos Santos D, Späth MR, Wahba R, Bruns CJ, Kleinert R.   +11 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source