Results 131 to 140 of about 394,851 (262)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

3D constructing: Exploring the potential of 3D concrete and clay printing with generative design for architectural innovation

Informes de la Construccion
The architectural and construction sectors are experiencing a transformative shift with the advent of 3D constructing. This research delves into the potential of 3D printing technologies when combined with generative design principles to reshape ...
Javier Alonso Madrid, Guillermo Sotorrio, Nils Olsson, José Antonio Tenorio   +3 more
doaj   +1 more source

Generative design approach to combine architected Voronoi foams with porous collagen scaffolds to create a tunable composite biomaterial. [PDF]

Acta Biomater, 2023
Dewey MJ, Chang RSH, Nosatov AV, Janssen K, Crotts SJ, Hollister SJ, Harley BAC.   +6 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Generative Design and Additive Manufacturing Techniques on the Optimization of Multi-MW Offshore Direct-Drive Wind Turbine Electrical Generators

Engineering Proceedings
New advances in structural optimization techniques and manufacturing methods, such as generative design (GD) and additive manufacturing (AM), are revolutionizing the capabilities to generate high-efficiency and lightweight models in comparison with ...
Daniel Gonzalez-Delgado, Pablo Jaen-Sola, Erkan Oterkus   +2 more
doaj   +1 more source

Controlling gene expression with deep generative design of regulatory DNA. [PDF]

Nat Commun, 2022
Zrimec J, Fu X, Muhammad AS, Skrekas C, Jauniskis V, Speicher NK, Börlin CS, Verendel V, Chehreghani MH, Dubhashi D, Siewers V, David F, Nielsen J, Zelezniak A.   +13 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Generative Design and Integrated 3D Printing Manufacture of Cross Joints. [PDF]

Materials (Basel), 2022
Han L, Du W, Xia Z, Gao B, Yang M.
europepmc   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Generative design of de novo proteins based on secondary structure constraints using an attention-based diffusion model. [PDF]

Chem, 2023
Ni B, Kaplan DL, Buehler MJ.
europepmc   +1 more source