Results 111 to 120 of about 309,839 (206)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2011 This work investigates the behavior of an electromagnetic micro-generator for power generation utilizing stray vibrations. The analysis is conducted through finite element simulations.
Rotaru, Mihai +2 more
core +1 more source
Analysis of Influence of Shear Flow of Lubricating Oil on Unstable Vibration of Generator Unit
Yuanzineng kexue jishuIn order to study the unstable vibration of generator unit in nuclear power plant, a rotor dynamics analysis model was established, in which the thermal effect induced by oil shear flow in bearing was considered.
LI Zhen1, , YANG Jiangang2, CHEN Huihui1, HE Mingyuan1, WANG Hongkai1
doaj +1 more source
SLOPPGEN: A Problem Generator for the Two-Dimensional Rectangular Single Large Object Placement Problem With a Single Defect [PDF]
In this paper, a problem generator for the Two-Dimensional Rectangular Single Large Object Placement Problem is presented. The parameters defining this problem are identified and described.
Vera Neidlein, Gerhard Wäscher
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Pattern Corruption-Assisted Physical Attacks Against Object Detection in UAV Remote Sensing
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingDeep neural networks (DNNs) have attained remarkable success in aerial detection tasks, yet they remain susceptible to adversarial samples, posing a significant challenge for their practical applications.
Yu Zhang +6 more
doaj +1 more source
florez-alberto/mock-fastq-generator: v0.0.1-alpha
<p>A generator of fastQ files based on random numbers and a template sequence.</p ...
Alberto Florez
core +1 more source