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Mutations in the APC gene and their implications for protein structure and function
Current Opinion in Genetics & Development, 1995An enormous number of germline and somatic mutations have been identified in the APC tumor suppressor gene. Nearly all of these mutations result in premature polypeptide chain termination, but the consequences to APC protein function are unknown. Recent advances, including the identification of an oligomerization domain, the localization of several ...
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APC gene and molecular diagnostics
2003Obiteljska adenomatozna polipoza (FAP) je autosomno dominantno nasljedna bolest povezana s povećanim rizikom oboljevanja od karcinoma debelog crijeva. U oboljelih se tijekom drugog ili trećeg desetljeća života na sluznici debelog crijeva razvija na stotine i tisuće adenomatoznih polipa koji pokazuju veliku sklonost zloćudnoj preobrazbi.
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Identification of APC gene mutations in Italian APC patients by PCR-SSCP analysis
1993The APC gene is a putative human tumor-suppressor gene responsible for adenomatous polyposis coli (APC), an inherited, autosomal dominant predisposition to colon cancer. It is also implicated in the development of sporadic colorectal tumors. The characterization of APC gene mutations in APC patients is clinically important because DNA-based tests can ...
L. Varesco +22 more
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Four novel germline mutations of the APC gene
Human Mutation, 1996D, Wells +4 more
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Hepatoblastoma as a Result of APC Gene Mutation
Journal of Pediatric Gastroenterology and Nutrition, 2012Maryna, Krawczuk-Rybak +3 more
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APC gene and presimptomatic genetic testing
2003Obiteljska adenomatozna polipoza (FAP) je autosomno dominantno nasljedna bolest povezana s povećanim rizikom oboljevanja od karcinoma debelog crijeva. U oboljelih se tijekom drugog ili trećeg desetljeća života na sluznici debelog crijeva razvija na stotine i tisuće adenomatoznih polipa koji pokazuju veliku sklonost zloćudnoj preobrazbi.
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