Results 111 to 120 of about 6,961,736 (332)

Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer. [PDF]

, 1987
Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals.
Bordignon, C, Eglitis, MA, Gillio, AP, Kantoff, PW, Karson, E, Kernan, NA, Kohn, DB, McLachlin, JR, Moen, RC, Yu, SF   +9 more
core  

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum [PDF]

, 2008
As nonreplicating tubercle bacilli are tolerant to the cidal action of antibiotics and resistant to multiple stresses, identification of this persister-like population of tubercle bacilli in sputum presents exciting and tractable new opportunities to ...
Alvarez, Anna L Sherratt, Bacon, Beste, Betts, Canetti, Claire Senner, Cole, Connolly, Conway, Daniel, Daugelat, Desjardin, Dhar, Dubnau, Eisen, Fenhalls, Fleischmann, Garnier, Garton, Gomez, Gurdyal S Besra, Jason Hinds, Kalscheuer, Karakousis, Kendall, Kolter, Kumar, Kumar Rajakumar, Larsen, Levin, Mangan, Manganelli, McKinney, Michael R Barer, Mitchison, Mitchison, Monahan, Mukamolova, Munoz-Elias, Murphy, Muttucumaru, Nakagawa, Natalie J Garton, Neyrolles, Olivier Neyrolles, Paramasivan, Park, Philip D Butcher, Rachman, Rajakumar, Rebecca J Smith, Reed, Richard A Adegbola, Rohde, Schnappinger, Shi, Siegele, Simon J Waddell, Sirakova, Smeulders, Sommers, Stewart, Su-Min Lee, Talaat, Talaat, Timm, Van der Geize, Voskuil, Waddell, Waddell, Waddell, Waltermann, Wayne, Wayne, Weichart, Wilkinson, Young   +77 more
core   +4 more sources

Consistent Metagenome-Derived Metrics Verify and Delineate Bacterial Species Boundaries

mSystems, 2020
There is controversy about whether bacterial diversity is clustered into distinct species groups or exists as a continuum. To address this issue, we analyzed bacterial genome databases and reports from several previous large-scale environment studies and
M. Olm, A. Crits-Christoph, Spencer Diamond, Adi Lavy, Paula B. Matheus Carnevali, J. Banfield   +5 more
semanticscholar   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Cronobacter, the emergent bacterial pathogen Enterobacter sakazakii comes of age; MLST and whole genome sequence analysis [PDF]

, 2014
Background: Following the association of Cronobacter spp. to several publicized fatal outbreaks in neonatal intensive care units of meningitis and necrotising enterocolitis, the World Health Organization (WHO) in 2004 requested the establishment of a ...
Dickins, B, Forsythe, SJ, Jolley, KA
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Transcriptome sequencing and expression analysis in peanut reveal the potential mechanism response to Ralstonia solanacearum infection

BMC Plant Biology
Background Bacterial wilt caused by Ralstonia solanacearum severely affects peanut (Arachis hypogaea L.) yields. The breeding of resistant cultivars is an efficient means of controlling plant diseases.
Xiao Wang, Feiyan Qi, Ziqi Sun, Hongfei Liu, Yue Wu, Xiaohui Wu, Jing Xu, Hua Liu, Li Qin, Zhenyu Wang, Suling Sang, Wenzhao Dong, Bingyan Huang, Zheng Zheng, Xinyou Zhang   +14 more
doaj   +1 more source

Identification of essential genes by transposon insertion sequencing and genome-scale metabolic model construction in Streptococcus suis

Microbiology Spectrum
Bacterial essential genes are indispensable for the survival of bacteria and therefore are attractive targets for novel anti-microbial drugs. Identifying essential genes provides a roadmap for developing novel antibiotics and anti-microbial therapies. In
Yongqing Zhang, Ruotong Gong, Menglei Liang, Liangsheng Zhang, Xiujian Liu, Jingzi Zeng, Mengli Yan, Dexin Qiu, Rui Zhou, Qi Huang   +9 more
doaj   +1 more source

Metagenome-Wide Association of Microbial Determinants of Host Phenotype in Drosophila melanogaster

mBio, 2014
Animal-associated bacteria (microbiota) affect host behaviors and physiological traits. To identify bacterial genetic determinants of microbiota-responsive host traits, we employed a metagenome-wide association (MGWA) approach in two steps.
John M. Chaston, Peter D. Newell, Angela E. Douglas   +2 more
doaj   +1 more source

Transcriptome analysis of Azospirillum lipoferum during its interaction with rice [PDF]

, 2012
The associative symbiosis between Plant Growth Promoting Rhizobacteria of the genus Azospirillum and cereals have mainly been studied from an agronomic and economic point of view, and several studies showed that plant morphological and metabolic changes ...
Borland, Stéphanie, Drogue, Benoit, Prigent-Combaret, Claire, Sanguin, Hervé, Wisniewski-Dyé, Florence   +4 more
core