Results 121 to 130 of about 1,092,358 (244)

Organoid‐Like Neurovascular Spheroids Promote the Recovery of Hypoxic‐Ischemic Skin Flaps Through the Activation of Autophagy

Advanced Healthcare Materials, EarlyView.
Highly sprouting organoid‐like neurovascular spheroids (NVUs) are developed, featuring cell‐loaded poly‐3‐hydroxybutyrate 4‐hydroxybutyrate(P34HB) porous microsphere cores embedded within Gelatin Methacryloyl. NVUs formed complex vascular plexuses and secreted extracellular matrix in vitro, simulating autologous nerves and blood interaction.
Junjin Jie, Jingyi Ju, Zhenxing Wang, Jun Chen, Lin‐Ping Wu, Jiaming Sun   +5 more
wiley   +1 more source

Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal‐Phenolic Networks

Advanced Healthcare Materials, EarlyView.
Small extracellular vesicles (sEVs) are encapsulated into protective shells composed of metal‐phenolic networks (MPNs) and secondary poly(ethylene glycol) layers. This surface modification approach enhances the storage stability of sEVs while maintaining their integrity and functionality. The shells can be selectively disassembled under mild conditions.
Chenyu Wang, Ailifeire Fulati, Kenta Kimura, Xianglan Li, Joseph J. Richardson, Mitsuru Naito, Kanjiro Miyata, Takanori Ichiki, Hirotaka Ejima   +8 more
wiley   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Tri‐Layered Bioactive Cutaneous Scaffold with Integrated Bioactive Metal Organic Frameworks to Promote Full‐Thickness Infected Diabetic Wound Healing: Multifaceted Therapeutic Strategies

Advanced Healthcare Materials, EarlyView.
The limitations of existing clinical treatments highlight the need for a more comprehensive strategy for addressing infected diabetic wounds. A tri‐layered scaffold is developed to deliver therapeutics loaded in CuBDC and ZIF‐8 MOFs that are tailored to the requirements of deep‐infected diabetic wounds.
Ayse Gunyakti Mujtaba, Ayşe Karakeçili, Berna Topuz, Barış Batur, Okan Onar, Mehmet Eray Elçiğir, Çağdaş Oto, Alireza Hanifehnezhad, Kaan Orhan   +8 more
wiley   +1 more source

Direct Surface Modification of the Epidermis Using Mussel‐Inspired Polydopamine with Multiple Anti‐Biofouling Functions

Advanced Healthcare Materials, EarlyView.
Surface modification using mussel‐derived polydopamine (PDA) is a versatile and robust biocompatible strategy that enables direct application to various epidermal surfaces, regardless of their morphological complexity or surface characteristics. The PDA‐coated epidermis exhibits multiple anti‐biofouling functionalities, including antibacterial and anti‐
Su Eon Lee, Hanna Lee, Jang Hwan Kim, Sungwook Park, Young Taek Oh, Hayoung Choi, Jeong‐Min Kim, Hye‐Jun Jo, Jun Hyun Park, Ho Jun Jin, Kwan Hyi Lee, Seung Ho Han, Hojun Kim, Jun Kyun Oh, Bong Hoon Kim   +14 more
wiley   +1 more source

Fabrication of a Lipopolysaccharide‐Targeting Peptide‐Based Colloid for Alleviating Carbapenem‐Resistant Enterobacteriaceae‐Induced Cutaneous Infection

Advanced Healthcare Materials, EarlyView.
In this study, a novel cationic peptide, IW is designed and synthesized, with a tandem‐repeat sequence demonstrating potent activities against a broad spectrum of clinically relevant Carbapenem‐resistant Enterobacteriaceae in both the planktonic and biofilm states. IW is then formulated with P407 to form IW‐P407 colloids.
Ping Zeng, Xinyi Ding, Chenyu Liu, Sheng Chen, Kin‐Fai Chan, Sharon Shui Yee Leung   +5 more
wiley   +1 more source

High‐Resolution Patterned Delivery of Chemical Signals From 3D‐Printed Picoliter Droplet Networks

Advanced Materials, EarlyView.
3D‐printed picoliter droplet networks have been fabricated that control gene expression in bacterial populations by releasing chemical signals with precise spatial definition and high temporal resolution. This system of effector release is widely applicable, offering diverse applications in biology and medicine.
Jorin Riexinger, Thomas Caganek, Xingzao Wang, Yutong Yin, Khoa Chung, Linna Zhou, Hagan Bayley, Ravinash Krishna Kumar   +7 more
wiley   +1 more source

A Bio‐Inspired Perspective on Materials Sustainability

Advanced Materials, EarlyView.
This perspective discusses natural materials as inspiration for sustainable engineering designs and the processing of materials. First, circularity, longevity, parsimony, and activity are presented as essential material paradigms. The perspective then uses many examples of natural and technical materials to introduce principles such as oligo ...
Wolfgang Wagermaier, Khashayar Razghandi, Peter Fratzl   +2 more
wiley   +1 more source

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

Advanced Materials, EarlyView.
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li, Dea Ilhamsyah, Benedict Tai, Yi Shen   +3 more
wiley   +1 more source

PezT: A Bacterial Suicide Gene

PLoS Biology, 2011
openaire   +5 more sources