Results 161 to 170 of about 72,402 (211)

The genetic landscape of breast cancer in young women from Morocco: implications for diagnosis and treatment. [PDF]

BMC Med Genomics
El Hejjioui B, Bouramtane A, Bouguenouch L, Elmakhzen B, Ahakoud M, Melhouf MA, Ouldim K, Bennis S.   +7 more
europepmc   +1 more source

Efficacy of olaparib in advanced cancers with somatic or germline mutations in BAP1, BARD1, BRIP1 and PALB2. [PDF]

ESMO Open
Joris S, Denys H, Collignon J, Rasschaert M, de Roodenbeke DT, Duhoux FP, Canon JL, Tejpar S, Mebis J, Decoster L, Aftimos P, De Grève J.   +11 more
europepmc   +1 more source

Genomic Predictors of Platinum Resistance and Survival in High-Grade Serous Ovarian Carcinoma: Insights from an Explorative Targeted Next-Generation Sequencing Analysis. [PDF]

Cancers (Basel)
De Marco C, Rocca V, Migliozzi S, Veneziano C, Gualtieri F, Cerantonio A, Butt TA, Santamaria G, De Angelis MT, Di Cello A, Venturella R, Zullo F, Viglietto G.   +12 more
europepmc   +1 more source

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BRCA1 gene: function and deficiency

International Journal of Clinical Oncology, 2017
The BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in cells. It is well known, along with BRCA 2, to cause hereditary breast and ovarian cancer, but here we will specifically focus on BRCA1.
Miho, Takaoka, Yoshio, Miki
openaire   +2 more sources

Functions of the BRCA1 and BRCA2 genes

Current Opinion in Genetics & Development, 1998
Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast cancer development. Both genes encode very large proteins of unknown function but recent results suggest that they may have roles in transcriptional regulation and DNA repair. These advances offer the prospect of understanding not only the normal cellular function of these genes but ...
D, Bertwistle, A, Ashworth
openaire   +2 more sources

In-Silico Analyses of Nonsynonymous Variants in the BRCA1 Gene

Biochemical Genetics, 2021
BReast CAncer gene 1 (BRCA1)-a tumor suppressor gene plays an important role in the DNA repair mechanism. Several BRCA1 variants perturb its structure and function, including synonymous and nonsynonymous single nucleotide polymorphisms (SNPs). In the present study, we performed in-silico analyses of nonsynonymous SNPs (nsSNPs) of the BRCA1 gene.
Sidra Arshad, Irfan Ishaque, Sidra Mumtaz, Muhammad Usman Rashid, Naila Malkani   +4 more
openaire   +2 more sources