Results 161 to 170 of about 1,685,955 (199)
MedComm, Volume 7, Issue 10, October 2026.Cooccurrence of dMMR and HRD in colorectal cancer. On the left blue shaded area, the dMMR (deficient mismatch repair) pathway is shown as a result of the loss of key DNA repair genes MLH1, MSH2, MSH6, and PMS2, which cause single strand breaks.
Xu Zhang +3 more
wiley +1 more source
Targeting the DNA Damage Response in Cancer
MedComm, Volume 7, Issue 10, October 2026.Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao +4 more
wiley +1 more source
Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments
MedComm, Volume 7, Issue 10, October 2026.Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma +9 more
wiley +1 more source
The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi +8 more
wiley +1 more source
Relating transcriptomics to protein abundance reveals self‐driven versus interactor‐driven proteins
Protein Science, Volume 35, Issue 10, October 2026.Abstract Statistically modeling the interdependence between transcriptomics and protein abundances remains a persistent challenge in bioinformatics research. Transcriptomic data and proteomic abundances typically display a moderate Pearson's correlation of about 0.5, while in tumor conditions, the correlation may decrease to a much weaker correlation ...
Loulwah Arnaout +2 more
wiley +1 more source
The Prostate, Volume 86, Issue 14, Page 1470-1476, October 2026.ABSTRACT Background [‐2]proPSA(p2PSA)‐related indices have demonstrated diagnostic value for detecting prostate cancer (PC) in males with modest increases in prostate‐specific antigen levels (PSA) of < 10 ng/mL. However, the “leak point” of p2PSA level in the blood circulation before developing screen‐detectable PC remains uncertain.
Yoshitaka Sekine +11 more
wiley +1 more source
The ‘Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease’ (PATROL) study
BJU International, Volume 138, Issue 4, Page 600-606, October 2026.Background Inherited (germline) pathogenic and likely pathogenic variants (gPVs) in key genes associated with increased risk of prostate cancer (PCa) now warrant more attentive PCa screening per National Comprehensive Cancer Network (NCCN) guidelines—e.g., BRCA2, HOXB13, ATM, BRCA1, MSH2, MSH6, CHEK2 and TP53.
Heather H. Cheng +12 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 18, 30 September 2026.Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín +11 more
wiley +1 more source
The evolving role of immunotherapy in ovarian cancer
Cancer, Volume 132, Issue 18, 15 September 2026.Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani +2 more
wiley +1 more source
Precision Chemistry for Protein Lysine Modification
Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley +1 more source