Results 171 to 180 of about 72,402 (211)

The dilemmas of a carrier of BRCA1 gene mutations

Patient Education and Counseling, 1998
This article describes that the decision to be tested on carriership of hereditary cancer has consequences that are more far-reaching than a potential carrier can anticipate beforehand. The experiences of a 41 year old woman, carrier of a mutated BRCA1 gene, who shortly before her scheduled bilateral breast amputation, decided not to have surgery, are ...
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Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women

Journal of Cancer Research and Clinical Oncology, 2009
BRCA1-interacting protein C-terminal helicase 1 (BRIP1) and zinc finger protein 350 (ZNF350) work with BRCA1 in tumor suppression procedures. Low penetrance variants of these three genes may jointly affect individuals' breast cancer susceptibility in general population.We focused on potentially functional single nucleotide polymorphisms (SNPs) in the ...
Xiang, Huo, Cheng, Lu, Xinen, Huang, Zhibin, Hu, Guangfu, Jin, Hongxia, Ma, Xuechen, Wang, Jianwei, Qin, Xinru, Wang, Hongbing, Shen, Jinhai, Tang   +10 more
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The BRCA1 and BRCA2 breast cancer genes

Current Opinion in Oncology, 1997
Between 5% and 10% of breast cancer cases result from an inherited predisposition. The majority of hereditary forms of breast and ovarian cancer can be accounted for by mutations in two recently identified genes, BRCA1 and BRCA2. Inactivating mutations have been found throughout both genes, and the majority are predicted to result in truncated proteins.
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Analysis of the BRCA1 and BRCA2 genes in sporadic meningiomas

Genes, Chromosomes and Cancer, 1997
Several lines of evidence suggest a relationship between the occurrence of meningiomas and that of breast carcinomas: Both occur more frequently in women than in men, and a higher incidence of meningiomas has been observed in patients with a history of breast carcinoma.
M, Kirsch, J J, Zhu, P M, Black
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BRCA1 Gene Sequence Variation in Centenarians

Annals of the New York Academy of Sciences, 2001
Abstract: With the ample gene sequence information that has become available with the human genome project virtually completed, it has become possible to identify functional gene variants and their frequencies in elderly populations with different aging‐related characteristics.
J, Vijg, T, Perls, C, Franceschi, N J, van Orsouw   +3 more
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BRCA1 and BRCA2 - breast cancer susceptibility genes

Journal of Cancer Research and Clinical Oncology, 2000
Genetic predisposition is responsible for 5% 10% of all breast cancer cases. Therefore, the inherited susceptibility to breast cancer has been intensively investigated during the last 10 years. In particular, the identification of the breast cancer susceptibility genes BRCA1 (breast cancer gene 1) and BRCA2 and the current genetic testing for mutations
W, Hofmann, P M, Schlag
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Males at‐risk for the BRCA1-gene, the psychological impact

Psycho‐Oncology, 1996
In recent literature the psychological impact of predictive DNA-testing for Hereditary Breast and Ovarian Cancer (HBOC) for male individuals at-risk has not been considered. We have observed that confrontation with the hereditary nature of breast/ovarian cancer does have a psychological impact on males at-risk.
de Wit, A. C. D., Tibben, A., Frets, P. G., Meijers-Heijboer, E. J., Devilee, P., Niermeijer, M. F.   +5 more
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BRCA1 Gene Mutation in Thymic Malignant Melanoma

The Annals of Thoracic Surgery, 2013
We present a patient with triple primary malignancies: thyroid cancer, ovarian cancer, and thymic malignant melanoma. We suspected that gene mutations were involved in the occurrence of these multiple primary cancers, and blood analysis revealed the presence of BRCA1 gene mutations.
Eun Jue, Yi, Jong Ho, Park, Hae Won, Lee, Soo Youn, Cho, Im Il, Na, Moon Chul, Kang   +5 more
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Premature Menopause in Patients with BRCA1 Gene Mutation

Breast Cancer Research and Treatment, 2006
This study was undertaken with regard to the gonadotropin theory of ovarian cancer advocated in the literature and was designed to disclose specific features of ovarian morphology in carriers of the BRCA1 gene mutation. We enrolled 171 patients and divided them into two groups: A (n=90)--operated for breast cancer (30 patients with and 60 without the ...
Izabella, Rzepka-Górska, Bogusław, Tarnowski, Anita, Chudecka-Głaz, Bohdan, Górski, Dorota, Zielińska, Aleksandra, Tołoczko-Grabarek   +5 more
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Gene Therapy for Breast and Ovarian Cancer with BRCA1

Breast Disease, 1998
As an initial step toward gene therapy for ovarian cancer, we conducted a Phase 1 trial to assess the pharmacokinetics and toxicity of intraperitoneal BRCA1sv retroviral vector therapy. Gene transfer and expression were documented by PCR, southern blot, RT-PCR and nuclease protection assays.
D L, Tait, R A, Jensen, J T, Holt, D H, Johnson, J, Gralow, M C, King   +5 more
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