Results 191 to 200 of about 115,309 (309)

Real‐world prevalence of PD‐L1 positivity in early‐stage/metastatic triple‐negative breast cancer: primary results and pathology insights from the global retrospective observational VANESSA study

Histopathology, Volume 88, Issue 7, Page 1373-1384, June 2026.
In the real‐world VANESSA study in triple‐negative breast cancer, PD‐L1‐positive prevalence was 38% in early‐stage and 20% in metastatic tumours, lower than in prospective trials. The lower prevalence in smaller versus larger tissue samples and by local versus central assessment underlines the importance of robust PD‐L1 testing to determine eligibility
Corrado D'Arrigo, Sitki Tuzlali, Romualdo Barroso‐Sousa, Nagi S El Saghir, Rebecca Dent, Nataša Medić‐Milijić, Gyungyub Gong, Shahin Sayed, Tu Thai Anh, Alisan Zirtiloglu, Götz Hartleben, Paula Toro, Iman Estaytieh, Enya Weber, Regula Deurloo, João Mouta, Lazar Popovic   +16 more
wiley   +1 more source

Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classification. [PDF]

EBioMedicine
Fortuno C, Zhang J, Koufariotis LT, Hollway G, Wood S, Pearson JV, Simpson PT, Lakhani SR, McCart Reed AE, Thorne H, Mann GB, Skandarajah AR, Devereux L, Zhao Q, De Silva DL, Lindeman GJ, Waring P, James PA, Campbell I, Spurdle AB, Waddell N.   +20 more
europepmc   +1 more source

Vaginal Microbiota and Ovarian Cancer: A New Frontier in Immunomodulation and Diagnosis

Immunology, Volume 178, Issue 2, Page 209-217, June 2026.
Microbial imbalance, dysbiosis, plays a role in ovarian carcinogenesis by interacting with the immune system and altering inflammatory pathways, notably Th17 pathways. In contrast, eubiosis, characterised by Lactobacillus dominance, protects against infections and maintains hormone metabolism.
Wafa Babay, Mariem Garci, Ahmed Baligh Laaribi, Nabil Mathlouthi, Imene Ouzari   +4 more
wiley   +1 more source

The genetic landscape of breast cancer in young women from Morocco: implications for diagnosis and treatment. [PDF]

BMC Med Genomics
El Hejjioui B, Bouramtane A, Bouguenouch L, Elmakhzen B, Ahakoud M, Melhouf MA, Ouldim K, Bennis S.   +7 more
europepmc   +1 more source

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source

Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt. [PDF]

Sci Rep
Ghebreselassie M, Park YJ, Nakib D, Dodington D, Patel P, Won S, Hakem A, Hakem R, MacParland S, Woo M.   +9 more
europepmc   +1 more source

Oncogenetic testing and follow-up for women with familial breast/ovarian cancer, Li-Fraumeni syndrome and Cowden syndrome [PDF]

, 2015
't Kint de Roodenbeke, Daphné, Berlière, Martine, Claes, Kathleen, Hulstaert, Frank, Janin, Nicolas, Matthijs, Gert, Poppe, Bruce, Robays, Jo, Stordeur, Sabine, Van Maerken, Tom, Wildiers, Hans   +10 more
core  

Germline genetic testing among patients with pancreatic adenocarcinoma: A Pancreatic Cancer Action Network patient survey

Cancer, Volume 132, Issue 10, 15 May 2026.
Abstract Background Approximately 10%–15% of patients with pancreatic ductal adenocarcinoma (PDAC) harbor pathogenic germline genetic alterations with direct therapeutic and hereditary cancer implications, leading to guideline recommendations for universal germline genetic testing regardless of family history.
Udhayvir S. Grewal, Rishi R. Patel, Bradley T. Loeffler, Sydney Rathjens, Kawther Abdilleh, Fatima Zelada‐Arenas, Nicholas J. Hornstein, Timothy J. Brown, Seth J. Concors, Naomi H. Fei, Saima Sharif, Chandrikha Chandrasekharan   +11 more
wiley   +1 more source

Cryptic redundancy between PAR1b and PAR1a, two members of the PAR1 kinase family, in the survival of PAR1b-knockout mice. [PDF]

Sci Rep
Murata-Kamiya N, Del Valle Lazarte AA, Kikuchi I, Hatakeyama M.   +3 more
europepmc   +1 more source

CEACAM6: A potential prognostic biomarker and therapeutic target in cholangiocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
Jia‐Qi Guo, Shi‐Jia Dai, Yang Liu, Zhen‐Gang Yuan   +3 more
wiley   +1 more source