Results 211 to 220 of about 115,309 (309)

Integrated Molecular Profiling Improves Subtype Classification and Reveals Inherited Susceptibility in Medulloblastoma: Insights From a Real‐World Cohort

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Medulloblastoma (MB) is a heterogeneous pediatric brain tumor characterized by distinct molecular subtypes. Although genomics and transcriptomics have improved subtype classification and informed targeted therapies, the clinical utility of integrated molecular profiling in real‐world settings remains incompletely defined. Methods We
Jiwei Song, Tiantian Han, Siqi Chen, Dongsheng Chen, Ziying Liu   +4 more
wiley   +1 more source

Commentary: With Regards to the WISDOM trial. [PDF]

BJC Rep
Narod SA.
europepmc   +1 more source

Germline Pathogenic Variants in HER2‐Positive Breast Cancer: Spectrum and Clinical Implications in a High‐Risk Chinese Cohort

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective Hereditary cancer risk assessment has predominantly focused on HER2‐negative breast cancer (BC), with limited characterization of germline pathogenic variants (GPVs) in HER2‐positive disease. This study aimed to delineate the prevalence, clinicopathological correlates, and clinical implications of GPVs in a cohort of HER2‐positive BC
Lijia Zhou, Mengqian Ni, Anli Yang, Qingru Zhou, Daining Wang, Shu Dun, Fei Xu, Jiajia Huang, Xiwen Bi, Wen Xia, Ruoxi Hong, Qiufan Zheng, Meiting Chen, Kuikui Jiang, Jun Tang, Xi Wang, Zhongyu Yuan, Shusen Wang, Yanxia Shi, Fang Wang, Xin An   +20 more
wiley   +1 more source

Genetic Testing in Breast Cancer: Narrative Review and Clinical Insights. [PDF]

Maedica (Bucur)
Bistriceanu I, Ungureanu CO, Stoica RA, Giuglea C, Grigorean VT, Roca D, Mihaila R, Iordache N, Ginghina O.   +8 more
europepmc   +1 more source

Advanced Gastric Cancer Presenting as a Giant Subepithelial Lesion: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
A giant subepithelial lesion. ABSTRACT Gastric cancer may occasionally present with a subepithelial lesion‐like appearance. When a gastric gastrointestinal stromal tumor (GIST) is suspected preoperatively without definitive pathological confirmation, intraoperative frozen section analysis is recommended to prevent inappropriate surgical intervention.
Ji Sun, Qian Wang, Yuemei Hu, Ping Yin, Ziming Zhou, Hui Chen, Xiaoming Zhu   +6 more
wiley   +1 more source

BRCA1/2 Reversion Mutations in Japanese Patients with Metastatic Breast Cancer Progressing on Olaparib: OLIVE (WJOG15321B). [PDF]

Breast Cancer
Sakai H, Kusumoto-Matsuo R, Hosonaga M, Nozawa K, Futamura M, Tanabe Y, Mukohara T, Shiraishi K, Toyama T, Yasojima H, Watanabe N, Sakai H, Iwasa T, Takeuchi N, Tada H, Sakai K, Chiba N, Takano T, Tsurutani J.   +18 more
europepmc   +1 more source

Resistance to neoadjuvant talazoparib in triple-negative breast cancer by BRN2-induced ATR/STAT3 pathways or SHLD2 subclone expansion. [PDF]

Proc Natl Acad Sci U S A
Abdulkareem NM, Jiang Y, Qi Y, Liu X, Zhang X, Cai S, Shao J, Jeter-Jones S, Rinkenbaugh AL, Cheng CC, Hancock F, Schwartz J, Litton JK, Chang JT, Piwnica-Worms H.   +14 more
europepmc   +1 more source

Clinical Significance of Biomarkers in Oropharyngeal Squamous Cell Carcinoma: Recurrence Prediction and Treatment Response

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Oropharyngeal squamous cell carcinoma (OPSCC) accounts for a substantial proportion of head and neck cancers, with a rising incidence largely driven by human papillomavirus (HPV) infection. Despite advances in multimodal treatment, disease recurrence remains common and limits long‐term survival, highlighting the need for reliable ...
Yunxia Chen, Wenyu Zhang, Xiang Gao, Kongling Xing, Yijing Ren, Jinyu Hu, Zhihao Xie, Ping Zhou   +7 more
wiley   +1 more source

Antiproliferative Effects of Cannabinoids and Cisplatin in Cervical Cancer Cells

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Introduction Cervical cancer remains a leading cause of cancer‐related mortality among women globally, particularly in low‐ and middle‐income countries. Cisplatin, a standard chemotherapeutic agent, is limited by severe toxicities and chemoresistance. This study aimed to assess the effects of cisplatin in combination with phytocannabinoids, Δ9‐
S. P. Mathibela, M. T. Lebelo, V. Steenkamp   +2 more
wiley   +1 more source

Combined Inhibition of ATR and Ribonucleotide Reductase Induces Synergistic Antineoplastic Activity in Osteosarcoma Cells

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Osteosarcoma is the most common bone cancer in children and young adults. Its prognosis has not improved significantly since the introduction of the chemotherapy regimen established about 40 years ago, highlighting the need for new therapeutic strategies.
Natalie Aderhold, Lisa Immesberger, Sabine Becker, Till Milde, Bernd Gruhn, Jürgen Sonnemann   +5 more
wiley   +1 more source