Results 51 to 60 of about 113,876 (211)

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation [PDF]

, 2016
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the
A Pijpe, A Vral, Anne Vral, Annelot Baert, B Ernestos, Bruce Poppe, D Goldfrank, E Febrer, EKJ Pauwels, EM John, F Cardinale, FJ Couch, Fransiska Malfait, G Sioftanos, GE Pantelias, Gianpaolo Perletti, GJ Heyes, H Nikjoo, I Cousineau, IM Obdeijn, J Barwell, J Depuydt, J Gronwald, J Lecarpentier, JC Drooger, JC Théry, Jenneke van den Ende, JL Bernheim, JM Hair, Julie Depuydt, K Claes, K Claes, K Claes, K Leeneer De, Kathleen B. M. Claes, Katrien Storm, KE Rieger, Kim De Leeneer, KW Caestecker, L Perrin-Vidoz, L Salmena, M Frankenberg-Schwager, M Sedic, ME Dextraze, MS Sasaki, N Andrieu, N Foray, N Li, O Anczuków, O Popanda, P Pfeiffer, P Willems, R Roy, RI Yarden, RJ Linger, S Gutiérrez-Enríquez, S Pathania, SA Narod, Sylvia De Nobele, T Vaclová, TA Buchholz, Tim Van Damme, Tom Van Maerken, U Hagen, V Giannakeas, WD Foulkes, Z Guo, Z Kote-Jarai   +67 more
core   +4 more sources

Expression of BRCA1 and BRCA2 Genes in Patients Undergoing Transrectal Prostate Biopsy

Revista Brasileira de Cancerologia
Introduction: Prostate cancer (PCa) is the second most common type of cancer among the male population. Men carrying mutations in the BRCA1 and BRCA2 genes are known to have a greater risk of developing PCa.
Eduardo Maciel Narvaes, Alyna Araújo e Marcondes, Roberto de Andrade Garcia Filho, Paulo Gabriel da Silva Mota, Patricia de Lima Lemos, Claudinéia de Araújo   +5 more
doaj   +1 more source

Patients with pathogenic variants for breast cancer other than BRCA1 and BRCA2: qualitative interviews about health care experiences

Hereditary Cancer in Clinical Practice, 2019
Background Genetic testing for hereditary cancer syndromes has been revolutionized by next-generation sequencing, which allows for simultaneous review of numerous genes.
Kristin E. Clift, Sarah K. Macklin, Stephanie L. Hines   +2 more
doaj   +1 more source

BRCA1 and BRCA2 as ovarian cancer susceptibility genes [PDF]

Carcinogenesis, 2005
Individuals carrying germline mutations in one allele of the BRCA1 or BRCA2 genes are at significantly increased risk of developing cancer. Although the increased risk of breast cancer is often highlighted, cancer at several other sites is also considerably more common in these individuals.
Heidi M, Sowter, Alan, Ashworth
openaire   +2 more sources

Allele-specific expression mediates primary resistance to poly (ADP-ribose) polymerase inhibitor therapy in a case of double-germline mutant gastric cancer

Journal of International Medical Research, 2020
Breast cancer gene 1 and 2 ( BRCA1 and BRCA2 ) are human tumor suppressor genes. BRCA mutations increase the risk for breast, ovarian, and gastric cancer.
Lu Wen, Xiuxiu Li, Junping Shi, Shuo Zhang, Rui Wang, Ming Yao, Jun Guo   +6 more
doaj   +1 more source

BRCA1 Regulates Gene Expression for Orderly Mitotic Progression [PDF]

Cell Cycle, 2005
Germline mutations of the BRCA1 gene confer an increased risk for breast cancer and ovarian cancer. To study the contribution of BRCA1 to sporadic cancers, which often exhibit reduced BRCA1 expression, we tested the effect of knocking down BRCA1 on gene expression in human prostate (DU-145) and breast (MCF-7) cancer cells.
Insoo, Bae, Jeong Keun, Rih, Hee Jeong, Kim, Hyo Jin, Kang, Bassem, Haddad, Alexander, Kirilyuk, Saijun, Fan, Maria L, Avantaggiati, Eliot M, Rosen   +8 more
openaire   +2 more sources

A theory for the tissue specificity of BRCA1/2 related and other hereditary cancers [PDF]

, 2010
Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast and ovarian cancer that are so high and seem so selective that many mutation carriers choose to have prophylactic surgery. There has been much conjecture to explain such apparently
Bernard Friedenson
core   +1 more source

Defective DNA repair mechanisms in prostate cancer: impact of olaparib [PDF]

, 2017
The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects.
De Felice, Francesca, Marampon, Francesco, Marchetti, Claudia, Musella, Angela, Tombolini, Vincenzo   +4 more
core   +2 more sources

A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer

BMC Medical Genetics, 2011
Background Germline mutations in either of the two tumor-suppressor genes, BRCA1 and BRCA2, account for a significant proportion of hereditary breast and ovarian cancer cases.
Llombart Pilar, Garcia Ana, Llopis Francisco, Rubio Luis, Fernandez-Serra Antonio, Romero Ignacio, Garcia-Casado Zaida, Lopez-Guerrero Jose A   +7 more
doaj   +1 more source

Identifying and testing for hereditary susceptibility to breast/ovarian cancer in Serbia: Where are we now? [PDF]

Archive of Oncology, 2006
About 90% of all breast cancers can be considered as sporadic, without inherited gene alteration. The rest of breast cancers (about 5 to 10%) are considered hereditary, most commonly caused by alterations of BRCA1/2 tumor suppressor genes. Lifetime risks
Branković-Magić Mirjana, Dobričić Jelena, Janković Radmila, Konstantopoulou Irene, Yannoukakos Drakoulis, Radulović Siniša   +5 more
doaj   +1 more source