Results 1 to 10 of about 6,532,899 (237)

Gene expression drives the evolution of dominance [PDF]

Nature Communications, 2017
AbstractDominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits. However, despite its importance, the degree of dominance in natural populations is poorly quantified.
Christian D. Huber, Arun Durvasula, Angela M. Hancock, Kirk E. Lohmueller   +3 more
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Candidate genes in ocular dominance plasticity [PDF]

Frontiers in Neuroscience, 2012
Many studies have been devoted to the identification of genes involved in experience-dependent plasticity in the visual cortex. To discover new candidate genes, we have reexamined data from one such study on ocular dominance (OD) plasticity in recombinant inbred BXD mouse strains. We have correlated the level of plasticity with the gene expression data
Rietman, M.L., Sommeijer, J.-P., Levelt, C.N., Heimel, J.A., Brussaard, A.B., Borst, J.G.G., Elgersma, Y., Galjart, N., van der Horst, G.T., Pennartz, C.M., Smit, A.B., Spruijt, B.M., Verhage, M., de Zeeuw, C.I.   +13 more
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Dominance from the perspective of gene–gene and gene–chemical interactions [PDF]

Genetica, 2015
In this study, we used genetic interaction (GI) and gene-chemical interaction (GCI) data to compare mutations with different dominance phenotypes. Our analysis focused primarily on Saccharomyces cerevisiae, where haploinsufficient genes (HI; genes with dominant loss-of-function mutations) were found to be participating in gene expression processes ...
Szymon Kaczanowski, Piotr Zielenkiewicz, Piotr Zielenkiewicz, Arkadiusz Gładki   +3 more
openaire   +3 more sources

A possible dominant white gene in Jersey cattle [PDF]

Genetics Selection Evolution, 2001
A white heifer ("Snow") was born in 1991 from coloured registered Jersey parents. She produced six calves sired by coloured Jersey bulls: three white bull calves, two white heifer calves, and one coloured bull calf. One of the white bull calves was mated with 40 Hereford x Friesian yearling heifers (white face, predominantly black body with some white ...
Morris, Chris, Phillip Sponenberg, D.
openaire   +5 more sources

Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22 [PDF]

, 2012
A substantial proportion of familial colorectal cancer (CRC) is not a consequence of known susceptibility loci, such as mismatch repair (MMR) genes, supporting the existence of additional loci.
Allyson S Templeton, Brenda Diergaarde, Brooke L Fridley, Colon CFR, D Timothy Bishop, Daniel Buchanan, Daniel J Serie, Duncan C Thomas, Ellen L Goode, Finlay A Macrae, Fredrick Schumacher, Graeme P Young, Graham Casey, H Banfield Younghusband, Ingrid Winship, Jane S Green, Joanne P Young, John D Potter, John L Hopper, Julie M Cunningham, Loic Le Marchand, Mark A Jenkins, Melissa S DeRycke, Mine S Cicek, Noralane M Lindor, Polly A Newcomb, Robert W Haile, Roger C Green, Stephen N Thibodeau, Steven Gallinger, Susan Parry, Theodore G Krontiris, William R Bamlet, Zhu Chen   +33 more
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Dominant constraints on the evolution of rhythmic gene expression

Computational and Structural Biotechnology Journal, 2022
AbstractAlthough the individual transcriptional regulators of the core circadian clock are distinct amongst different organisms, the autoregulatory feedback loops they form are conserved. This unified design principle explains how daily physiological activities oscillate across species.
Yang Cheng, Yuhao Chi, Linying Sun, Guang-Zhong Wang   +3 more
openaire   +3 more sources

Variation of Dominance of Newly Arisen Adaptive Genes [PDF]

Genetics, 1997
Newly arisen adaptive alleles such as insecticide resistance genes represent a good opportunity to investigate the theories put forth to explain the molecular basis of dominance and its possible evolution. Dominance levels of insecticide resistance conferred by insensitive alleles of the acetylcholinesterase gene were analyzed in five resistant strains
Bourguet, Denis, Lenormand, Thomas, Guillemaud, Thomas, Marcel, Véronique, Fournier, Didier, Raymond, Michel   +5 more
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Gene Therapy for Autosomal Dominant Disorders of Keratin [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2005
Dominant mutations that interfere with the assembly of keratin filaments cause painful and disfiguring epidermal diseases like pachyonychia congenita and epidermolysis bullosa simplex. Genetic therapies for such diseases must either suppress the production of the toxic proteins or correct the genetic defect in the chromosome.
Alfred S. Lewin, Leonard M. Milstone, Peter M. Glazer   +2 more
openaire   +3 more sources

A dominant repressor version of the tomatoSl-ERF.B3gene confers ethylene hypersensitivity via feedback regulation of ethylene signaling and response components [PDF]

, 2013
Ethylene Response Factors (ERFs) are downstream components of the ethylene signal transduction pathway, although their role in ethylene-dependent developmental processes remains poorly understood. As the ethylene-inducible tomato Sl-ERF.B3 has been shown
Achard, Allen, Alonso, Benavente, Berrocal-Lobo, Bleecker, Brown, Chakravarthy, Chao, Dubois, Fujimoto, Gu, Gu, Hall, Hao, Heyl, Hiratsu, Hua, Johnson, Ju, Kevany, Kevany, Kieber, Leclercq, Lee, Li, Lin, Magome, Matsui, Matsui, McGrath, Mitsuda, Nakano, Ohme-Takagi, Oñate-Sánchez, Pan, Pirrello, Pirrello, Pré, Riechmann, Sasaki, Solano, Solano, Tieman, Tieman, Tournier, Trujillo, van der Fits, Wang, Wuriyanghan, Yokotani, Zhang   +51 more
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Further genetic heterogeneity for autosomal dominant human sutural cataracts [PDF]

, 2003
A unique sutural cataract was observed in a 4-generation German family to be transmitted as an isolated autosomal, dominant trait. Since mutations in the gamma-crystallin encoding CRYG genes have previously been demonstrated to be the most frequent ...
Billingsley, G., Graw, Jochen, Heon, E., Illig, T., Klopp, N., Rudolph, G., Wjst, M.   +6 more
core   +1 more source