Results 11 to 20 of about 488,818 (245)

Nucleolar dominance and ribosomal RNA gene silencing [PDF]

Current Opinion in Cell Biology, 2010
Nucleolar dominance is an epigenetic phenomenon that occurs in genetic hybrids and describes the expression of 45S rRNA genes inherited from one progenitor due to the silencing of the other progenitor's rRNA genes. Nucleolar dominance is a manifestation of rRNA gene dosage control, which also occurs in non-hybrids, regulating the number of active rRNA ...
Sarah, Tucker, Alexa, Vitins, Craig S, Pikaard   +2 more
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Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes

Scientific Reports, 2021
Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology.
Anna Esteve-Codina, Thomas P. Hofer, Dorothe Burggraf, Marion S. Heiss-Neumann, Wolfgang Gesierich, Anne Boland, Robert Olaso, Marie-Therese Bihoreau, Jean-Francois Deleuze, Winfried Moeller, Otmar Schmid, María Soler Artigas, Kathrin Renner, Jens M. Hohlfeld, Tobias Welte, Thomas Fuehner, Lukas Jerrentrup, Andreas Rembert Koczulla, Timm Greulich, Antje Prasse, Joachim Müller-Quernheim, Sumit Gupta, Christopher Brightling, Deepak R. Subramanian, David G. Parr, Umme Kolsum, Vandana Gupta, Imre Barta, Balázs Döme, János Strausz, Mariarita Stendardo, Marco Piattella, Piera Boschetto, Damian Korzybski, Dorota Gorecka, Adam Nowinski, Marc Dabad, Marcos Fernández-Callejo, David Endesfelder, Wolfgang zu Castell, Pieter S. Hiemstra, Per Venge, Elfriede Noessner, Thasso Griebel, Simon Heath, Dave Singh, Ivo Gut, Loems Ziegler-Heitbrock   +47 more
doaj   +1 more source

Missense mutations in EDA and EDAR genes cause dominant syndromic tooth agenesis

Molecular Genetics & Genomic Medicine, 2021
Background Hypohidrotic ectodermal dysplasia (HED) is the most common form of ectodermal dysplasia and is mainly associated with mutations in the EDA, EDAR, and EDARADD responsible for the development of ectodermal‐derived structures.
Francesca Andreoni, Claudia Sgattoni, Daniela Bencardino, Oriana Simonetti, Antonino Forabosco, Mauro Magnani   +5 more
doaj   +1 more source

Allele-specific silencing of dominant disease genes [PDF]

Proceedings of the National Academy of Sciences, 2003
Small interfering RNA (siRNA) holds therapeutic promise for silencing dominantly acting disease genes, particularly if mutant alleles can be targeted selectively. In mammalian cell models we demonstrate that allele-specific silencing of disease genes with siRNA can be achieved by targeting either a linked single-nucleotide polymorphism
Victor M, Miller, Haibin, Xia, Ginger L, Marrs, Cynthia M, Gouvion, Gloria, Lee, Beverly L, Davidson, Henry L, Paulson   +6 more
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Dominant transcript expression profiles of human protein-coding genes interrogated with GTEx dataset

Scientific Reports, 2022
The discovery and quantification of mRNA transcripts using short-read next-generation sequencing (NGS) data is a complicated task. There are far more alternative mRNA transcripts expressed by human genes than can be identified from NGS transcriptome data
Kuo-Feng Tung, Chao-Yu Pan, Wen-chang Lin   +2 more
doaj   +1 more source

Inheritance of spike color in einkorn wheat (Triticum monococcum L.)

Вісник Харківського Національного Університету Імені В.Н. Каразіна: Серія Біологія, 2022
Aim: specify the spike color inheritance in einkorn wheat (Triticum monococcum L.) hybrids. Methods: reciprocal hybrids between the black-spikeed UA0300282 and white-spikeed UA0300311 cultivated einkorn accessions were created with the use of the “single
Hao Fu
doaj   +1 more source

Gene expression drives the evolution of dominance [PDF]

Nature Communications, 2017
Abstract Dominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits. However, despite its importance, the degree of dominance in natural populations is poorly quantified.
Christian D. Huber, Arun Durvasula, Angela M. Hancock, Kirk E. Lohmueller   +3 more
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Genomic Architecture of Yield Performance of an Elite Rice Hybrid Revealed by its Derived Recombinant Inbred Line and Their Backcross Hybrid Populations

Rice, 2022
Background Since its development and wide adoption in China, hybrid rice has reached the yield plateau for more than three decades. To understand the genetic basis of heterosis in rice and accelerate hybrid rice breeding, the yield performances of the ...
Fan Zhang, Conghe Zhang, Xiuqin Zhao, Shuangbing Zhu, Kai Chen, Guixiang Zhou, Zhichao Wu, Min Li, Tianqing Zheng, Wensheng Wang, Zhi Yan, Qinyong Fei, Zhikang Li, Jinjie Chen, Jianlong Xu   +14 more
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Molecular Mechanisms of Isolated Polycystic Liver Diseases

Frontiers in Genetics, 2022
Polycystic liver disease (PLD) is a rare autosomal dominant disorder including two genetically and clinically distinct forms: autosomal dominant polycystic kidney disease (ADPKD) and isolated polycystic liver disease (PCLD).
Ziqi Yu, Xiang Shen, Chong Hu, Jun Zeng, Aiyao Wang, Jianyong Chen   +5 more
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Deciphering the mode of action and position of genetic variants impacting on egg number in broiler breeders

BMC Genomics, 2020
Background Aim of the present study was first to identify genetic variants associated with egg number (EN) in female broilers, second to describe the mode of their gene action (additive and/or dominant) and third to provide a list with implicated ...
Eirini Tarsani, Andreas Kranis, Gerasimos Maniatis, Santiago Avendano, Ariadne L. Hager-Theodorides, Antonios Kominakis   +5 more
doaj   +1 more source