Results 101 to 110 of about 5,543,352 (313)

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Role and molecular mechanisms of HuangQiSiJunZi decoction for treating triple-negative breast cancer as explored via network pharmacology and bioinformatics analyses

BMC Cancer
Objective In this study, we evaluated the molecular mechanisms of HuangQiSiJunZi Decoction (HQSJZD) for treating triple-negative breast cancer (TNBC) using network pharmacology and bioinformatics analyses.
Decai Wang, Dongqing Xie, Shuai Meng, Jiwei MI, Haiming Wang, Lingsheng Li, Yin Zhang, Yixin Cui   +7 more
doaj   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Modulation of c-fos gene expression by amplification

, 1993
Bibliography: p. 163-197.
openaire   +2 more sources

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, EarlyView.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

Abnormal c-Fos expression in TetTag mice containing fos-EGFP

Frontiers in Behavioral Neuroscience
Molecular and genetic techniques now allow selective tagging and manipulation of the population of neurons, often referred to as “engram cells,” that were active during a specific experience.
Jacob H. Wilmot, Jacob H. Wilmot, Tracy L. Warren, Tracy L. Warren, Tracy L. Warren, Cassiano R. A. F. Diniz, Deger Carda, Deger Carda, Marrisa M. Lafreniere, Alex S. Nord, Alex S. Nord, Alex S. Nord, Brian J. Wiltgen, Brian J. Wiltgen   +13 more
doaj   +1 more source

Research on Heat Transfer Enhancement of Spiral Grooved Tube Heat Exchangers Based on CFD and Artificial Intelligence

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Driven by the energy crisis and carbon neutrality goals, high‐efficiency heat exchange equipment has become a core demand in the industrial sector. The spiral grooved double‐pipe heat exchanger exhibits significant heat transfer enhancement advantages, yet it requires balancing heat transfer efficiency and pressure loss.
Yueyun Yang, Wei Li, Xiuzhi Xi, Neng Gao
wiley   +1 more source

Fun‐sized library prep: Miniaturization is a valid method for per‐sample cost reduction in targeted sequencing of angiosperm DNA

Applications in Plant Sciences, EarlyView.
Abstract Premise Genomic analysis of population structure is important for understanding plant genetic diversity among and within populations. A limitation to the broader application of genetics in conservation and related fields is the cost of obtaining large datasets.
Madison R. Bullock, Mohamed Fokar, Rylee D. Creek, Eliot A. Stevens, Matthew G. Johnson   +4 more
wiley   +1 more source

Morphological variation in atlas and axis of Neotropical spiny rats (Rodentia, Echimyidae)

The Anatomical Record, EarlyView.
Abstract The unique morphologies of the first two cervical vertebrae, the atlas and axis, represent a significant innovation in mammalian evolution. These structures support the weight of the head and enable intricate movements of the head and neck.
Thomas Furtado da Silva Netto, João Felipe Leal Kaiuca, Adriana Itatí Olivares, William Corrêa Tavares   +3 more
wiley   +1 more source

Synergistic and antagonistic activities of IRF8 and FOS enhancer pairs during an immune-cell fate switch

The EMBO Journal
Cell fate instructive genes tend to be regulated by large clusters of enhancers. Whether and how individual enhancers within such clusters cooperate in regulating gene expression is poorly understood.
Antonios Klonizakis, Marc Alcoverro-Bertran, Pere Massó, Joanna Thomas, Luisa de Andrés-Aguayo, Xiao Wei, Vassiliki Varamogianni-Mamatsi, Christoforos Nikolaou, Thomas Graf   +8 more
doaj   +1 more source