Results 171 to 180 of about 5,543,352 (313)

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Role of Macrophage-Related Genes GAS7 and ZEB2 in Acute Myocardial Infarction Pathogenesis. [PDF]

Hum Mutat
Liu Z, Song J, Li L, Fan Z, Xie G, Yang L.   +5 more
europepmc   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Shear Stress Promotes Metastasis of Triple-negative Breast Cancer Cells Through Calcium Channel-ROS-FOS Axis. [PDF]

Int J Biol Sci
Xiong H, Zhou M, Luo KQ.
europepmc   +1 more source

Porous Organic Polymers: From Molecular Design to Scalable Technologies

Small, EarlyView.
This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem, Hadi Shayesteh, Simindokht Zarei‐Shokat, Rokhsareh Bakhtiari, Sheyda Abedi‐Banaei, Zahra Sheikhlouiharzand, Parnia Mohebimanesh, Seyed Mohammad Amin Ojagh, Bahareh Bakhtiari, Ali Maleki, Theo G. M. van de Ven, Sohrab Zendehboudi, Ali Elkamel   +12 more
wiley   +1 more source

scRNA-seq reveals different cell clusters in the testes of Mongolian cattle and EGR1/FOS/JUN regulation in Sertoli cells. [PDF]

Sci Rep
Gao S, Zhang S, Ren H, Yang H, Wang L, He J, Zhang J, Zhang G, Mengke B, Zhu L, Qi Q, Aierqing S, Fan R, Herrid M.   +13 more
europepmc   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

Lateral Habenula 5-HT₂A Receptors Mediate Social Deficits in a Valproic Acid-Induced Rodent Model of Autism Spectrum Disorder. [PDF]

Mol Neurobiol
Zhang C, Sang H, Zhang B, Zhao Z, Shang H, Wang X, Luan S, Wang J.   +7 more
europepmc   +1 more source

Genetic population structure of red foxes Vulpes vulpes across a rural landscape: insights into population connectivity and spatial patterns

Wildlife Biology, EarlyView.
Human activities have shaped and are continuing to influence terrestrial landscapes, creating heterogenous, and often, fragmented landscapes. Generalist species, like the red fox Vulpes vulpes, show high flexibility in habitat use, and occur across the heterogeneous, anthropogenic landscapes of central Europe.
Lukas G. Scholz, Felicitas Oehler, Florian Kunz, Robert Hagen, Niko Balkenhol, Cornelia Ebert, Thomas Alef, Manisha Bhardwaj, Janosch Arnold, Gisela Kopp, Ilse Storch   +10 more
wiley   +1 more source

One-year multicenter surveillance of Fosfomycin resistance Enterobacterales: the rise of FosA3-producing <i>P. mirabilis</i>. [PDF]

Curr Res Microb Sci
Chudejova K, Mattioni Marchetti V, Zaccaria V, Kanova S, Sramkova A, Krutova M, Ryskova L, Kroneislova G, Horvathova B, Tejkalova R, Krejci E, Vagnerova I, Zemanova Z, Bitar I.   +13 more
europepmc   +1 more source