Results 181 to 190 of about 140,486 (305)

Indirect Striatal Projection Neurons Drive a D2 Receptor‐Dependent Pathway to Dyskinesia and Dystonia

Movement Disorders, EarlyView.
D2 receptor ablation in indirect‐pathway striatal neurons reduces or abolishes dyskinetic and dystonic behaviors induced by L‐DOPA or D2 receptor agonists, respectively. Contralateral turning is reduced, while forward locomotion is increased. These effects are associated with modulation of neuronal activity in dorsal striatum and external globus ...
Laura Andreoli, Teodor Nyman, Elena Espa, Johan Jakobsson, Osama F. Elabi, Maria Angela Cenci   +5 more
wiley   +1 more source

A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities. [PDF]

Front Immunol
Gao W, Lin Z, Bao Y, Liu M, Ma G, Chen X, Yu S, Zeng Y.   +7 more
europepmc   +1 more source

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress. [PDF]

J Neuroendocrinol
Gueissaz L, Sideromenos S, Tretiakov EO, Schnell R, Harkany T.   +4 more
europepmc   +1 more source

Engaging the public in plant science: Communication facilitators and barriers of scaling up a citizen science campaign

People and Nature, EarlyView.
Abstract Volunteers have been involved in nature observations for decades through citizen science initiatives, providing large data sets as well as problem identification that allow a more complete understanding of many natural phenomena. Although communication is a core component in citizen science, the key factors that determine its effectiveness in ...
Kristiina Gibson, Monika Suškevičs, Baiba Prūse, Marta Barberis, Sara A. O. Cousins, Živa Fišer, Margaux Julien, Marianne Kivastik, Marcin Klisz, Attila Lengyel, Zuzana Münzbergová, Radosław Puchałka, Iris Reinula, Froukje Rienks, Julie Koch Sheard, Viktor Siverin, Bojana Stojanova, Sabrina Träger, Tsipe Aavik   +18 more
wiley   +1 more source

When invasions go unnoticed: Public perception of the freshwater jellyfish Craspedacusta sowerbii in Europe

People and Nature, EarlyView.
Abstract Biological invasions are a major driver of biodiversity loss, yet inconspicuous or “cryptic” species often escape detection and public awareness, limiting management responses. We investigated the freshwater jellyfish Craspedacusta sowerbii, likely native to China and now present on six continents, through a 22‐month multilingual online survey
Guillaume Marchessaux, Kristína Slovák Švolíková, Barbora Števove, Ali Serhan Tarkan, Daniela Giannetto, Cristina Preda, Belma Kalamujić Stroil, Maciej K. Mańko, András Abonyi, Álmos Becz, Massimo Morpurgo, Evgeny A. Pakhomov, Levan Mumladze, Mar Bosch‐Belmar, Aino Hosia, Patricia Ventura, Jamileh Javidpour, Florian Lüskow   +17 more
wiley   +1 more source

Exploring the Potential Roles of Oxidative Stress-Related Genes in Thyroid Eye Disease and Graves' Disease. [PDF]

J Ophthalmol
Zhang W, Huang Q, Jinying Li.
europepmc   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, EarlyView.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in an in vitro cell-of-origin model for osteoid osteoma and osteoblastoma. [PDF]

J Pathol
Lam SW, Belova T, Franceschini N, van den Akker B, van IJzendoorn DG, Mikkers HM, Mei H, Cleton-Jansen AM, Kuijjer ML, Szuhai K, Bovée JV.   +10 more
europepmc   +1 more source

A Gene Expression Tumor Signature Optimizing Partial Area‐Under‐the‐Curve (pAUC) to Improve Specificity for Indolent Prostate Cancer

The Prostate, EarlyView.
ABSTRACT Purpose A key clinical challenge in prostate cancer is the identification and validation of biomarkers with high specificity for indolent long‐term outcomes. We applied a novel statistical method to identify tumor transcriptomic biomarkers that optimally predicted patients with low metastatic potential.
Travis A. Gerke, Svitlana Tyekucheva, Konrad H. Stopsack, Christopher J. Sweeney, Rosina T. Lis, Elizabeth N. Westling, Massimo Loda, Meir J. Stampfer, Kathryn L. Penney, Giovanni Parmigiani, Lorelei A. Mucci   +10 more
wiley   +1 more source