Results 181 to 190 of about 142,631 (286)

Identification of key genes predicting the efficacy of mepolizumab in the treatment of severe eosinophilic asthma. [PDF]

Sci Rep
Xinmin P, Jinxia C, Fengyuan L.
europepmc   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

Integrated Single-Cell and Bulk Transcriptomics Unveils Immune Profiles in Chick Erythroid Cells upon Avian Pathogenic Escherichia coli Infection. [PDF]

Animals (Basel)
Cai F, Wang X, Wang C, Wang Y, Zhang W.
europepmc   +1 more source

Combined Effects of Puerarin and Adipose‐Derived Stem Cells on Alveolar Bone Preservation and Inflammation Control in Periodontitis Through p38MAPK Modulation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley   +1 more source

A cell-state axis underlying colonization in carcinomas with implications for metastasis risk prediction and interception. [PDF]

Cell Rep
Handler JS, Li Z, Dveirin RK, Lin JD, Fang W, Wu S, Forsmo JE, Goodarzi H, Fertig EJ, Kalhor R.   +9 more
europepmc   +1 more source

Soil Nail Design Optimization Through Adaptive Slope Stability Analysis Using Improved Limit Equilibrium Method

International Journal for Numerical and Analytical Methods in Geomechanics, EarlyView.
ABSTRACT Design optimization for automatically generating optimal design results is a promising technique for enhancing the efficiency of design processes and outcomes. However, its development for soil nail reinforced slopes is limited since the traditional slope stability analysis using the limit equilibrium method (LEM) becomes relatively time ...
Weihang Ouyang, Kai Liu, Si‐Wei Liu
wiley   +1 more source

Mechanistic Evaluation of Roxadustat for Pulmonary Fibrosis: Integrating Network Pharmacology, Transcriptomics, and Experimental Validation. [PDF]

Pharmaceuticals (Basel)
Zhang C, Huang X, Ye H, Tang H, Huang M, Jia S, Shao J, Wu J, Yao X.   +8 more
europepmc   +1 more source

Uncovering a new species of Hemileccinum (Boletaceae, Basidiomycota) from India with morphological characteristics and multi‐gene molecular phylogeny

Nordic Journal of Botany, EarlyView.
While undertaking macrofungal forays to several forested areas of Uttarakhand (India), a noteworthy and previously unknown species of Hemileccinum was unveiled. This species is proposed here as Hemileccinum indicum sp. nov. It is presented with both morphological characteristics and multigene molecular phylogenetic analysis.
Kanad Das, Sudeshna Datta, Alfredo Vizzini, Aniket Ghosh   +3 more
wiley   +1 more source

Transcriptome analysis identifies EDA1 variants disrupt FOSB-mediated regulation of odontogenic epithelial cell behaviors during dental germ development. [PDF]

Front Cell Dev Biol
Zhang J, Kong X, Yuan Y, Zhao Y, Ding Y, Ren J, Shen W.   +6 more
europepmc   +1 more source

Engaging the public in plant science: Communication facilitators and barriers of scaling up a citizen science campaign

People and Nature, EarlyView.
Abstract Volunteers have been involved in nature observations for decades through citizen science initiatives, providing large data sets as well as problem identification that allow a more complete understanding of many natural phenomena. Although communication is a core component in citizen science, the key factors that determine its effectiveness in ...
Kristiina Gibson, Monika Suškevičs, Baiba Prūse, Marta Barberis, Sara A. O. Cousins, Živa Fišer, Margaux Julien, Marianne Kivastik, Marcin Klisz, Attila Lengyel, Zuzana Münzbergová, Radosław Puchałka, Iris Reinula, Froukje Rienks, Julie Koch Sheard, Viktor Siverin, Bojana Stojanova, Sabrina Träger, Tsipe Aavik   +18 more
wiley   +1 more source