Results 201 to 210 of about 142,631 (286)

Enhanced <i>FOS</i> expression improves tumor clearance and resists exhaustion in NR4A3-deficient CAR T cells under chronic antigen exposure. [PDF]

Sci Adv
Yin P, Yang J, Jiang Y, Han L, Xiong T, Liu H, Fang Y, Ruan W, Wu J, Chen L, Tan L, Zuo Y, Wu X, Mao F, Huang R, Liu X, Bian XW.   +16 more
europepmc   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, EarlyView.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

Enhancement of melanoma aggressiveness via p38-MAPK, HIF-1α pathways, and metabolic reprogramming induced by Candida albicans. [PDF]

Sci Rep
Aparicio-Fernandez L, Cazalis-Bereicua N, Areitio M, Rodriguez-Erenaga O, Abio-Dorronsoro L, Martin-Souto L, Buldain I, Márquez J, Benedicto A, Arteta B, Macias-Cámara N, Gonzalez M, Rodriguez JEM, Aransay AM, Pellon A, Moyes DL, Anguita J, Rementeria A, Antoran A, Ramirez-Garcia A.   +19 more
europepmc   +1 more source

‘Mere Amateurs’? Elementary Teachers and the Making of Scientific Authority in the British Child Study Movement

History, EarlyView.
Abstract This article offers new perspectives on the relationship between elementary teaching, scientific expertise and the professionalization of the human sciences. Previous scholarship has demonstrated the ready existence of ‘amateur’ science societies in the nineteenth century where cross‐class exchanges were common.
Julia Gustavsson
wiley   +1 more source

Single-cell resolution spatial transcriptomic signature of the retrosplenial cortex during memory consolidation. [PDF]

Mol Psychiatry
Bliese SR, Basu B, Beyer SE, Elsadany M, Michaelson JJ, Chatterjee S.   +5 more
europepmc   +1 more source

Prenatal Environmental Hypoxia Enhances Adult Hypoxia Tolerance in Brandt's Voles (Lasiopodomys brandtii): Behavioral and Transcriptomic Insights

Integrative Zoology, EarlyView.
Prenatal hypoxia enhances adult hypoxia tolerance in Brandt's voles, preserving cognitive and memory functions. Transcriptomic analysis reveals adaptive changes in energy metabolism, oxygen transport, and neuroprotective mechanisms, highlighting developmental plasticity.
Mengyang Li, Congcong Qiao, Xiujuan Li, Maolin Huang, Zhenlong Wang, Luye Shi   +5 more
wiley   +1 more source

The two faces of MyoD: repressor and activator of gene expression during myogenesis. [PDF]

Genes Dev
Birchmeier C.
europepmc   +1 more source

Cenozoic Tectonics Ignite Mitochondrial Codon Innovations Propelling Canid Body Size Evolution and Transcontinental Radiations

Integrative Zoology, EarlyView.
We decode mitochondrial genomes across all extant canids, revealing lineage‐specific codon optimization driven by altitude, predation, and body size. A tripartite framework integrates geological events, metabolic constraints, and adaptive radiation to explain carnivore evolution.
Xiaoyang Wu, Xibao Wang, Yongquan Shang, Yao Chen, Haotian Cai, Tian Xia, Qinguo Wei, Weilai Sha, Honghai Zhang   +8 more
wiley   +1 more source