Results 231 to 240 of about 142,631 (286)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Machine learning-enhanced discovery of a basement membrane-related gene signature in glioblastoma via single-cell and Spatial transcriptomics. [PDF]

J Transl Med
Liu Z, Yang Y, Fang H, Han M, Qi P, Fan Y, Li J, He S, Wang L.   +8 more
europepmc   +1 more source

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

RBM25 Regulates p38 MAPK Pathway Activation via Exon 16 Skipping of MAP4K4 in a Rat Model of Post-Infarction Heart Failure. [PDF]

FASEB Bioadv
Li H, Zhang K, Liu C, Tian X, Zhou G, Liu W, Li Y, Zhao L, Wang L, Yang P.   +9 more
europepmc   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

Nutritional c-Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity-Associated Hepatocellular Carcinoma. [PDF]

Adv Sci (Weinh)
Li A, Gilglioni EH, St-Pierre-Wijckmans W, Hosseinzadeh L, Veyrat-Durebex C, Singh SP, Coppari R, Bakiri L, Gurzov EN.   +8 more
europepmc   +1 more source

Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor‐like lectin

The FEBS Journal, EarlyView.
We characterize the PLTL lectin from Photorhabdus laumondii, which adopts a unique TNF‐like fold. Binding assays reveal a preference for branched histo‐blood group oligosaccharides. Protein crystallography uncovers a novel hexameric assembly and identifies key residues involved in carbohydrate recognition.
Filip Melicher, Pavel Dobeš, Jan Komárek, Lukáš Faltinek, Marek Korsák, Petra Sýkorová, Josef Houser, Michaela Wimmerová   +7 more
wiley   +1 more source

Unraveling Cytomegalovirus Drug Resistance in Transplant Patients by Targeting Deep Sequencing. [PDF]

J Med Virol
Alemán S, Camacho J, Recio V, Ruiz E, Zamarrón P, Anel J, Enjuto M, Tarragó D.   +7 more
europepmc   +1 more source

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

The FEBS Journal, EarlyView.
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider   +8 more
wiley   +1 more source

Aligned piezoelectric fibrous scaffolds for prevention of traumatic neuroma formation. [PDF]

Front Bioeng Biotechnol
Chen Y, Gu X, Zang H, Wang C, Li G.
europepmc   +1 more source