Results 241 to 250 of about 5,543,352 (313)

The Role of FOS in Gene Regulation

1990
The cellular protooncogene FOS is expressed at very low level in most cells of the organism and in most growing cells in culture. The synthesis is rapidly elevated if cells are exposed to one of a large number of agents and conditions. This suggests that FOS is an intermediate in the signal transfer of a variety of different specific genetic responses.
Herrlich, P., Ponta, H., Stein, B., Gebel, S., Koenig, H., Schoenthal, A., Buescher, M., Rahmsdorf, H. J.   +7 more
openaire   +1 more source

Induction of c- fos Gene Expression by Interferons

Journal of Interferon Research, 1988
We show that murine interferons (IFNs)-alpha/beta and -gamma induce expression of the protooncogene c-fos in F9 embryonal carcinoma cells, NIH-3T3 cells, and other tissue culture cells. The induction of c-fos mRNA is rapid and transient in that the mRNA appears within 15 min and disappears by 2 h following IFN treatment. The protein synthesis inhibitor
Y J, Wan, B Z, Levi, K, Ozato
openaire   +2 more sources

Alteration of c-fos gene methylation in human gliomas

Molecular Carcinogenesis, 1996
In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of ...
S, Uyeno, J, Komura, R, Tawa, Y, Aoki, M, Nata, H, Sasano, H, Nakura, K, Sagisaka, H, Sakurai, T, Kayama, T, Yoshimoto, T, Ono   +11 more
openaire   +2 more sources

Expression of the C-Fos Gene During Differentiation

1987
Retroviruses cause tumors in experimental animals via a number of diverse mechanisms. One group of viruses induces transformation by introduction of a viral gene (v-onc) derived from a normal cellular gene (c-onc) (1–3). In general, acquisition of the c-onc gene is accompanied by various alterations, including single base changes and deletions, and ...
C, Van Beveren, R L, Mitchell, C, Henning-Chubb, E, Huberman, I M, Verma   +4 more
openaire   +2 more sources

Retinal degeneration, apoptosis and the c-fos gene

Neuro-Ophthalmology, 1998
In the past few years, the interest in the research field of apoptosis in the retina has been growing rapidly. We will give a short overview of apoptosis in the context of retinal degeneration and summarize recent data obtained in our laboratory. Based on our findings, we will also discuss possible future strategies to influence apoptotic cell death in
Farhad Hafezi, Andreas Wenzel, Christian Grimm, Charlotte E. Remé   +3 more
openaire   +1 more source

Proto-oncogene fos: a multifaceted gene

Trends in Genetics, 1986
Abstract Both v- fos and c- fos proteins, despite their altered carboxyl terminus, are nuclear and can transform fibroblasts in vitro . The c- fos protein exhibits complex regulation involving interaction with 3′ non-coding sequences of c- fos RNA.
openaire   +1 more source

c-fos antisense RNA blocks expression of c-fos gene in F9 embryonal carcinoma cells

Cell Differentiation and Development, 1988
To study the function of proto-oncogene c-fos, we prepared an antisense plasmid that expresses in mammalian cells c-fos antisense RNA which is complementary to the endogenous c-fos mRNA. Upon transfection into undifferentiated F9 EC cells, the antisense plasmid directed constitutive expression of a large amount of c-fos antisense RNA.
B Z, Levi, J W, Kasik, K, Ozato
openaire   +2 more sources

Fos is not involved in the regulation of the proenkephalin gene by haloperidol in the mouse striatum

Molecular Brain Research, 1995
The aim of the study was to determine whether the haloperidol-produced induction of the c-fos gene in the mouse striatum is the cause of the increased expression of the striatal proenkephalin (PENK) gene after repeated haloperidol administration. Mice were treated with haloperidol (1 mg/kg, i.p., once daily), MK-801 (1 mg/kg, i.p., twice daily), or ...
B, Ziółkowska, V, Höllt
openaire   +2 more sources

c-fos gene expression in rat liver is induced by phenobarbital

Cancer Letters, 1999
In the present study we investigated c-fos expression in rat livers, that was initiated with the three arylamines, 2-acetylaminofluorene, 2-acetylaminophenanthrene and trans-4-acetylaminostilbene. The tumor promoter phenobarbital was applied chronically for 26, 52 and 100 weeks.
A, Bitsch, C, Duebelbeiss, A, Greiner
openaire   +2 more sources

Proto-oncogene fos: an inducible gene.

Princess Takamatsu symposia, 1988
Proto-oncogene fos is a multifaceted gene, which is expressed during cell growth, cell differentiation, and development. The viral homologue, v-fos, was identified as the resident transforming gene of FBJ-murine osteosarcoma virus which induces bone tumors in mice.
I M, Verma, R L, Mitchell, P, Sassone-Corsi   +2 more
openaire   +1 more source