Results 71 to 80 of about 140,486 (305)

Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 [PDF]

, 2009
We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt ...
Atsushi Yoshiki, Hitomi Hasegawa, Jianzhi Pan, Kazunari K. Yokoyama, Koji Nakade, Naoto Yamaguchi, Satoko Masuzaki, Takehide Murata, Yu-Chang Huang, Yuichi Obata   +9 more
core   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. [PDF]

, 2015
The current knowledge on how transcription factors (TFs), the ultimate targets and executors of cellular signalling pathways, are regulated by protein-protein interactions remains limited.
Anna Malovannaya, David H Hawke, Jiadong Wang, Jun Qin, Junjie Chen, Kaestner KH, Rudy Guerra, Wei Li, Wenqi Wang, Xu Li, Yuanxin Xi   +10 more
core   +2 more sources

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Regulatory motif discovery using a population clustering evolutionary algorithm [PDF]

, 2007
This paper describes a novel evolutionary algorithm for regulatory motif discovery in DNA promoter sequences. The algorithm uses data clustering to logically distribute the evolving population across the search space. Mating then takes place within local
Lones, Michael A., Tyrrell, Andy M.
core   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Integrative Bulk and Single-Cell Transcriptomic Profiling Reveals Oxidative Stress-Related Genes and Potential Therapeutic Targets in Osteoarthritis

Mediators of Inflammation
Osteoarthritis (OA) is increasingly recognized as a degenerative joint disease that leads to a serious problem of public health, yet the underlying molecular mechanisms remain incompletely understood. In this study, we integrated bulk and single-cell RNA
Jinhui Peng, Jinzhong Chen, Duan Gao, Bowei Liang, Zongquan Huang, Bo Xiong, Shuheng Zhou, Guanghai Tan, Zhihui Zhong, Xianghong Zeng   +9 more
doaj   +1 more source

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms [PDF]

, 2014
Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, though
A Agrawal, A De Cian, A Goltsov, A Graudenzi, A Schonthal, A Subramanian, A Tapias, A Tapias, A von Kriegsheim, A Wuensche, AE Bilsland, AE Bilsland, AE Bilsland, AE Bilsland, Alan E. Bilsland, B Tang, C Jiang, C Lawless, C Torres-Sosa, CJ Anderson, Claire J. Cairney, D Hanahan, D Machado, D Xu, DE Nelson, DG Johnson, DH Crouch, DJ Billingsley, DL Crowe, DR White, E Yang, EJ Black, F Gizard, FW Huang, G Niu, G Wrobel, H Yuan, J Cho, J Grefenstette, J Won, J Zhao, JN Davis, Jon Roffey, JS Ho, K Cho, K Jiang, K Lafferty-Whyte, K Lafferty-Whyte, K Lafferty-Whyte, K Ookawa, K Thalmeier, K Willadsen, Katrina Stevenson, KI Zeller, KJ Wu, KM Ryan, L Chen, L Durant, L Konnikova, LA Bell, LC Freeman, LE Sivak, LG Wooten-Blanks, LI Chen, M Choi, M Daniel, M Kohl, M Nicolas, M Takakura, N Arkus, N Benson, N Kley, OE Akman, OW Rokhlin, P Angel, PJ Killela, PM Neilsen, Q Wang, R Duan, R Schlatter, R Wilds, RT Sitaram, S Horn, S Hossain, S Huang, S Kauffman, S Kyo, S Mangan, S Oh, Satoru Miyano, SM Mac, SP Hsu, Stacey Hoare, SY Lin, T Kanaya, T Maki-Marttunen, T Sengupta, TG Oliver, TH Kim, U Moehren, V Anest, V Batagelj, VJ Gnanapragasam, VK Mootha, W. Nicol Keith, WB Lee, X Chen, Y Xiao, Y Xing, Y Yao, Yu Liu   +110 more
core   +3 more sources