Results 61 to 70 of about 140,486 (305)

Expression of c‐fos gene inhibits proteoglycan synthesis in transfected chondrocyte [PDF]

FEBS Letters, 1996
The effect of expression of c‐fos gene on proteoglycan synthesis, one of the important markers of cartilage metabolism, was examined by introducing the c‐fos DNA into HCS 2/8 chondrocytes. The [35S]sulfate incorporation into proteoglycan was decreased in the c‐fos transfectants expressing exogenous c‐fos mRNA, when compared to a control transfectant. A
Tsuji, Michiko, Funahashi, Shin-ichi, Takigawa, Masaharu, Seiki, Motoharu, Fujii, Katsuyuki, Yoshida, Takeshi   +5 more
openaire   +2 more sources

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.

PLoS ONE, 2016
To investigate the prevalence, location and genetic environments of fosfomycin-resistance (fos) genes in methicillin-resistant Staphylococcus aureus (MRSA) clinical strains, 67 fosfomycin-resistant MRSA strains were isolated from the blood and ...
Zhuyingjie Fu, Yang Liu, Chunhui Chen, Yan Guo, Ying Ma, Yang Yang, Fupin Hu, Xiaogang Xu, Minggui Wang   +8 more
doaj   +1 more source

Spontaneous and cytokine regulated c-fos gene expression in rheumatoid synovial cells: resistance to cytokine stimulation when the c-fos gene is overexpressed [PDF]

Annals of the Rheumatic Diseases, 2000
To study the effect of cytokines on the transactivation of the c-fos gene in relation to the contribution of overexpression of c-fos/AP-1 in rheumatoid joint destruction.The promoter region (-447 to +109) of the human c-fos gene was integrated upstream of the chloramphenicol acetyltransferase (CAT) reporter gene, and the effect of cytokines on the ...
K, Shimizu, H, Kawasaki, T, Morisawa, M, Nakamura, E, Yamamoto, N, Yoshikawa, M, Doita, K, Shiozawa, S, Yonehara, K, Chihara, S, Shiozawa   +10 more
openaire   +2 more sources

Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma [PDF]

, 2016
BACKGROUND: Growing evidence is showing that metastatic cell populations are able to transfer their characteristics to less malignant cells. Exosomes (EXOs) are membrane vesicles of endocytic origin able to convey their cargo of mRNAs, microRNAs (miRs),
Bellenghi, Maria, Carè, Alessandra, Coscia, Carolina, Errico, Maria Cristina, Felicetti, Federica, Feo, Alessandra De, Pagani, Elena, Pasquini, Luca, Pedini, Francesca, Puglisi, Rossella   +9 more
core   +5 more sources

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Defining the chromatin signature of inducible genes in T cells [PDF]

, 2016
BACKGROUND Specific chromatin characteristics, especially the modification status of the core histone proteins, are associated with active and inactive genes. There is growing evidence that genes that respond to environmental or developmental signals may
Bunting, Karen, Chen, Xinxin, Hardy, Kristine, Lim, Pek S, Ma, Lina, Peng, Kaiman, Shannon, Mary F   +6 more
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

MECHANISMS OF IMMEDIATE-EARLY GENES ACTIVATION

Медицинский вестник Юга России, 2016
In our article, we focus on molecular mechanisms of immediately early genes expression. We discuss extracellular signals that are transduced into the nucleus through a variety of signaling mechanisms to elicit changes in patterns of immediately early ...
P. P. Polyakov, A. S. Lipatova, A. H. Kade   +2 more
doaj   +1 more source