Results 61 to 70 of about 5,543,352 (313)

Subgroup of meningiomas involving FOS and FOSB gene fusions

Nature Communications
Meningiomas are the most common primary tumors of the central nervous system and are typically treated with surgery or radiation, as targeted therapies remain limited. Despite extensive study, seventeen percent of meningiomas lack known genetic drivers.
Kanat Yalcin, Hasan Alanya, Batur Gultekin, Diego Samper Figuera, Tanyeri Barak, Danielle F. Miyagishima, Mark W. Youngblood, Mateo Gomez Hjerthen, Amos Brooks, Natalia Samuel Lopez, Joseph O’Brien, Miguel Millares Chavez, Alper Dincer, Hao Wu, S. Bulent Omay, Katsuhito Yasuno, Kaya Bilguvar, A. Gulhan Ercan-Sencicek, Ketu Mishra-Gorur, Declan McGuone, Jennifer Moliterno, Murat Gunel, E. Zeynep Erson-Omay   +22 more
openaire   +2 more sources

Engineered Carbon Dots from a Traditional Herb Pair Orchestrate Concurrent Antioxidant and AP‐1‐Mediated Inflammation to Attenuate Renal Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study integrates two complementary traditional Chinese medicine components as precursors to synthesize bioactive AM‐AS@CDs. Compared with single‐component CDs, these dual‐component CDs exhibit enhanced antioxidant capacity and superior renoprotective effects.
Bixiao Liu, Fuying Zhu, Zhuqing Wang, Jiawen Chen, Xiaomiao Cui, Congzhong Yang, Yao Peng, Dengyuan Feng, Li Lu, Hui Wei, Xiaozhi Zhao   +10 more
wiley   +1 more source

Expression of c‐fos gene inhibits proteoglycan synthesis in transfected chondrocyte [PDF]

FEBS Letters, 1996
The effect of expression of c‐fos gene on proteoglycan synthesis, one of the important markers of cartilage metabolism, was examined by introducing the c‐fos DNA into HCS 2/8 chondrocytes. The [35S]sulfate incorporation into proteoglycan was decreased in the c‐fos transfectants expressing exogenous c‐fos mRNA, when compared to a control transfectant. A
Tsuji, Michiko, Funahashi, Shin-ichi, Takigawa, Masaharu, Seiki, Motoharu, Fujii, Katsuyuki, Yoshida, Takeshi   +5 more
openaire   +2 more sources

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

fos protooncogene and the regulation of gene expression in adipocyte differentiation. [PDF]

The Journal of cell biology, 1988
ELLULAR development occurs in several stages in higher eukaryotic organisms. This process is generally characterized by the loss of pluripotency and restriction of possible cell fates, leading to a highly "determined" cell that can either proliferate or differentiate into a defined end-type cell.
B M, Spiegelman, R J, Distel, H S, Ro, B S, Rosen, B, Satterberg   +4 more
openaire   +2 more sources

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Integrative Bulk and Single-Cell Transcriptomic Profiling Reveals Oxidative Stress-Related Genes and Potential Therapeutic Targets in Osteoarthritis

Mediators of Inflammation
Osteoarthritis (OA) is increasingly recognized as a degenerative joint disease that leads to a serious problem of public health, yet the underlying molecular mechanisms remain incompletely understood. In this study, we integrated bulk and single-cell RNA
Jinhui Peng, Jinzhong Chen, Duan Gao, Bowei Liang, Zongquan Huang, Bo Xiong, Shuheng Zhou, Guanghai Tan, Zhihui Zhong, Xianghong Zeng   +9 more
doaj   +1 more source

Functional analysis of the role of CcpA in Lactobacillus plantarum grown on fructooligosaccharides or glucose: a transcriptomic perspective

Microbial Cell Factories, 2018
Background The catabolite control protein A (CcpA) is a master regulator of many important cellular processes in Gram-positive bacteria. In Lactobacillus plantarum, CcpA directly or indirectly controls the transcription of a large number of genes that ...
Yanqing Lu, Sichao Song, Huaixiang Tian, Haiyan Yu, Jianxin Zhao, Chen Chen   +5 more
doaj   +1 more source

Transcription factor c-fos induces the development of premature ovarian insufficiency by regulating MALAT1/miR-22-3p/STAT1 network

Journal of Ovarian Research, 2023
Background The current study attempted to investigate the role of transcription factor c-fos in the development of premature ovarian insufficiency (POI) as well as the underlying mechanism involving the MALAT1/miR-22-3p/STAT1 ceRNA network.
Ting Qiu, Jie Zhou, Bing Ji, Liuyang Yuan, Tingsong Weng, Huishu Liu   +5 more
doaj   +1 more source