IL-10 production in macrophages is regulated by a TLR-driven CREB-mediated mechanism that is linked to genes involved in cell metabolism [PDF]
, 2015 IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections, macrophages are an important source of IL-10; however, the molecular mechanism underpinning production of IL-10 by ...
Mountford, Adrian P. +2 more
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Genomic analyses of aminoacyl tRNA synthetases from human-infecting helminths
BMC Genomics, 2019 Background Helminth infections affect ~ 60% of the human population that lives in tropical and subtropical regions worldwide. These infections result in diseases like schistosomiasis, lymphatic filariasis, river blindness and echinococcosis.
Preeti Goel, Suhel Parvez, Amit Sharma
doaj +1 more source
Molecular helminthology in the Rockies [PDF]
, 2005 A report on the Keystone Symposium on Molecular Helminthology, Copper Mountain, Colorado, USA, 9-13 April ...
Blaxter, M.
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Frontiers in Immunology, 2022 Dietary probiotics may enhance gut health by directly competing with pathogenic agents and through immunostimulatory effects. These properties are recognized in the context of bacterial and viral pathogens, but less is known about interactions with ...
Laura J. Myhill +11 more
doaj +1 more source
Differential Changes in Expression of Intestinal Antimicrobial Peptide Genes During Ascaris lumbricoides Infection in Zambian Adults Do Not Respond to Helminth Eradication [PDF]
The Journal of Infectious Diseases, 2011 Intestinal helminthiasis modulates immune responses to vaccines and environmental allergens. To explore the impact on intestinal host defense, we assessed expression of antimicrobial peptide genes, together with T cell subset markers and cytokines, in patients with ascariasis before and after treatment.Case patients (n = 27) and control subjects (n ...
Max Katubulushi +6 more
openaire +5 more sources
Recombinant expression systems: the obstacle to helminth vaccines? [PDF]
, 2007 A
Claerebout, Edwin +3 more
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, 2021 Symbiont microbial communities play important roles in animal biology and are thus considered integral components of metazoan organisms, including parasitic worms (helminths). Nevertheless, the study of helminth microbiomes has thus far been largely overlooked, and symbiotic relationships between helminths and their microbiomes have been only ...
Formenti, Fabio +3 more
openaire +4 more sources
Nematode control in 'green' ruminant production systems [PDF]
, 2004 Collectively, nematode parasites of domestic ruminants continue to pose the greatest disease problem in grazing livestock systems worldwide, despite the powerful and extensive chemotherapeutic arsenal available for their control.
Thamsborg, Stig M., Waller, Peter J.
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A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis? [PDF]
, 2012 Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages.
Allen, JT +3 more
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Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. [PDF]
, 2006 Immunophilin is the collective name given to the cyclophilin and FK506-binding protein (FKBP) families. As the name suggests, these include the major binding proteins of certain immunosuppressive drugs: cyclophilins for the cyclic peptide cyclosporin A ...
Adams +101 more
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