Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1. [PDF]
PLoS ONE, 2016 Helminth infections and allergic diseases are associated with IgE hyperresponsiveness but the genetics of this phenotype remain to be defined. Susceptibility to Ascaris lumbricoides infection and antibody levels to this helminth are associated with ...
Nathalie Acevedo +8 more
doaj +1 more source
B cell fate mapping reveals their contribution to the memory immune response against helminths
Frontiers in Immunology, 2022 An estimated quarter of the human world population is infected with gastrointestinal helminths causing major socioeconomic problems in endemic countries.
Paul Haase +5 more
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Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis [PDF]
, 2009 Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured.
Maizels, R M
core +1 more source
The landscape of human genes involved in the immune response to parasitic worms
BMC Evolutionary Biology, 2010 Background More than 2 billion individuals worldwide suffer from helminth infections. The highest parasite burdens occur in children and helminth infection during pregnancy is a risk factor for preterm delivery and reduced birth weight.
Fumagalli Matteo +6 more
doaj +1 more source
Plasticity of migrating CD1b+ and CD1b- lymph dendritic cells in the promotion of Th1, Th2 and Th17 in response to Salmonella and helminth secretions. [PDF]
PLoS ONE, 2013 Dendritic cells (DCs) are pivotal in the development of specific T-cell responses to control pathogens, as they govern both the initiation and the polarization of adaptive immunity.
Michel Olivier +4 more
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The host immune response to gastrointestinal nematode infection in sheep [PDF]
, 2015 non peer reviewedGastrointestinal nematode infection represents a major threat to the health, welfare and productivity of sheep populations worldwide. Infected lambs have a reduced ability to absorb nutrients from the gastrointestinal tract, resulting in
Abraham +113 more
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Expression of Ascaris lumbricoides putative virulence-associated genes when infecting a human host
Parasites & Vectors, 2021 Background Ascaris lumbricoides is the most common causative agent of soil-transmitted helminth infections worldwide, with an estimated 450 million people infected with this nematode globally.
Norashikin Mohd-Shaharuddin +3 more
doaj +1 more source
IL-10 production in macrophages is regulated by a TLR-driven CREB-mediated mechanism that is linked to genes involved in cell metabolism [PDF]
, 2015 IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections, macrophages are an important source of IL-10; however, the molecular mechanism underpinning production of IL-10 by ...
Mountford, Adrian P. +2 more
core +1 more source
Mucosal immune responses following intestinal nematode infection. [PDF]
, 2014 In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years).
Else KJ +11 more
core +4 more sources
Nematode control in 'green' ruminant production systems [PDF]
, 2004 Collectively, nematode parasites of domestic ruminants continue to pose the greatest disease problem in grazing livestock systems worldwide, despite the powerful and extensive chemotherapeutic arsenal available for their control.
Thamsborg, Stig M., Waller, Peter J.
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