Results 21 to 30 of about 12,335 (183)

Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression [PDF]

ASN Neuro, 2015
In neurocysticercosis, parasite-induced immune suppressive effects are thought to play an important role in enabling site-specific inhibition of inflammatory responses to infections. It is axiomatic that microglia-mediated (M1 proinflammatory) response causes central nervous system inflammation; however, the mechanisms by which helminth parasites ...
Arun Chauhan, Fredice Z. Quenum, Ata Abbas, David S. Bradley, Sergei Nechaev, Brij B. Singh, Jyotika Sharma, Bibhuti B. Mishra   +7 more
openaire   +4 more sources

Searching for antigen B genes and their adaptive sites in distinct strains and species of the helminth Echinococcus [PDF]

Infection, Genetics and Evolution, 2006
Twenty-seven PCR-derived antigen B (AgB) nucleotide sequences from four Echinococcus species (Echinococcus granulosus, Echinococcus multilocularis, Echinococcus oligarthrus and Echinococcus vogeli) were aligned with 78 already published sequences, to generate a maximum likelihood phylogeny of the AgB multigene family. The phylogenetic analysis confirms
Haag, KL, Zanotto, PMA, Alves-Junior, L, Gasser, RB, Zaha, A, Ayala, FJ   +5 more
openaire   +4 more sources

Expression of Ascaris lumbricoides putative virulence-associated genes when infecting a human host

Parasites & Vectors, 2021
Background Ascaris lumbricoides is the most common causative agent of soil-transmitted helminth infections worldwide, with an estimated 450 million people infected with this nematode globally.
Norashikin Mohd-Shaharuddin, Yvonne Ai Lian Lim, Romano Ngui, Sheila Nathan   +3 more
doaj   +1 more source

Haemonchus contortus P-glycoproteins interact with host eosinophil granules: a novel insight into the role of ABC transporters in host-parasite interaction. [PDF]

PLoS ONE, 2014
Eosinophils are one of the major mammalian effector cells encountered by helminths during infection. In the present study, we investigated the effects of eosinophil granule exposure on the sheep parasitic nematode Haemonchus contortus as a model.
Mohamed Issouf, Fabrice Guégnard, Christine Koch, Yves Le Vern, Alexandra Blanchard-Letort, Hua Che, Robin N Beech, Dominique Kerboeuf, Cedric Neveu   +8 more
doaj   +1 more source

Lower expression of TLR2 and SOCS-3 is associated with Schistosoma haematobium infection and with lower risk for allergic reactivity in children living in a rural area in Ghana.

PLoS Neglected Tropical Diseases, 2008
BackgroundHelminth infections are prevalent in rural areas of developing countries and have in some studies been negatively associated with allergic disorders and atopy.
Franca C Hartgers, Benedicta B Obeng, Yvonne C M Kruize, Marjolijn Duijvestein, Anna de Breij, Abena Amoah, Irene A Larbi, Ronald van Ree, Michael D Wilson, Laura C Rodrigues, Daniel A Boakye, Maria Yazdanbakhsh   +11 more
doaj   +1 more source

Effect of heterogeneous mixing and vaccination on the dynamics of anthelmintic resistance: a nested model. [PDF]

PLoS ONE, 2010
Anthelmintic resistance is a major threat to current measures for helminth control in humans and animals. The introduction of anthelmintic vaccines, as a complement to or replacement for drug treatments, has been advocated as a preventive measure.
Lorenzo Sabatelli
doaj   +1 more source

Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen [PDF]

Genes & Immunity, 2004
Since interleukin (IL)-10 is a key mediator of immunosuppression, and immunosuppression is considered an important element of helminth infection, we studied variants of the putative IL-10 gene promoter in 337 individuals from 130 families heavily exposed to infection by the tissue nematode Onchocerca volvulus.
C, Timmann, S, Fuchs, C, Thoma, B, Lepping, N W, Brattig, J, Sievertsen, T, Thye, B, Müller-Myhsok, R D, Horstmann   +8 more
openaire   +2 more sources

The Immune and Non-Immune Pathways That Drive Chronic Gastrointestinal Helminth Burdens in the Wild

Frontiers in Immunology, 2018
Parasitic helminths are extremely resilient in their ability to maintain chronic infection burdens despite (or maybe because of) their hosts’ immune response.
Simon A. Babayan, Wei Liu, Graham Hamilton, Elizabeth Kilbride, Evelyn C. Rynkiewicz, Melanie Clerc, Amy B. Pedersen   +6 more
doaj   +1 more source

Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4Rα-independent alternative differentiation of macrophages.

PLoS Pathogens, 2013
Approximately one-third of the world's population suffers from chronic helminth infections with no effective vaccines currently available. Antibodies and alternatively activated macrophages (AAM) form crucial components of protective immunity against ...
Julia Esser-von Bieren, Ilaria Mosconi, Romain Guiet, Alessandra Piersgilli, Beatrice Volpe, Fei Chen, William C Gause, Arne Seitz, J Sjef Verbeek, Nicola L Harris   +9 more
doaj   +1 more source

Molecular phylogenetics and systematics of two enteric helminth parasites (Baylisascaris laevis and Diandrya vancouverensis) in the Vancouver Island marmot (Marmota vancouverensis)

International Journal for Parasitology: Parasites and Wildlife, 2022
Island biogeography can promote rapid diversification and speciation via geographic isolation and novel selection pressures. These same factors can threaten the persistence of island endemics by limiting gene flow and suitable habitat.
McIntyre A. Barrera, Jasmine K. Janes, Jamieson C. Gorrell   +2 more
doaj   +1 more source