Investigating the development of diarrhoea through gene expression analysis in sheep genetically resistant to gastrointestinal helminth infection [PDF]
Scientific Reports, 2022 Gastrointestinal helminths infect livestock causing health problems including severe diarrhoea. To explore the underlying biological mechanisms relating to development and control of diarrhoea, we compared 4 sheep that were susceptible to development of ...
Shamshad Ul Hassan +7 more
doaj +3 more sources
Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on
Veterinary Research, 2011 Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and
Lühken Gesine +3 more
doaj +4 more sources
Comparative transcriptomics of stickleback immune gene responses upon infection by two helminth parasites, Diplostomum pseudospathaceum and Schistocephalus solidus [PDF]
Zoology, 2016 Immune systems of vertebrates are much more diverse than previously thought, in particular at the base of the vertebrate clade. RNA-seq was used to describe in detail the transcriptomic response of stickleback hosts to infection by two helminth parasites,
Bornberg-Bauer, Erich +8 more
core +5 more sources
Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells [PDF]
Frontiers in ImmunologyBackgroundAscaris lumbricoides cystatin (Al-CPI) prevents the development of allergic airway inflammation and dextran-induced colitis in mice models. It has been suggested that helminth-derived cystatins inhibit cathepsins in dendritic cells (DC), but ...
Nathalie Acevedo +7 more
doaj +4 more sources
Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression [PDF]
ASN Neuro, 2015 In neurocysticercosis, parasite-induced immune suppressive effects are thought to play an important role in enabling site-specific inhibition of inflammatory responses to infections. It is axiomatic that microglia-mediated (M1 proinflammatory) response causes central nervous system inflammation; however, the mechanisms by which helminth parasites ...
Arun Chauhan +7 more
openaire +4 more sources
Gene expression patterns during adaptation of a helminth parasite to different environmental niches [PDF]
Genome Biology, 2007 Abstract Background Schistosome bloodflukes are complex trematodes responsible for 200 million cases of schistosomiasis worldwide. Their life cycle is characterized by a series of remarkable morphological and biochemical transitions between an invertebrate host, an aquatic environment, and a mammalian ...
Emmitt R. Jolly +6 more
openaire +4 more sources
HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization. [PDF]
PLoS ONE, 2011 A vast majority of the burden from neglected tropical diseases result from helminth infections (nematodes and platyhelminthes). Parasitic helminthes infect over 2 billion, exerting a high collective burden that rivals high-mortality conditions such as ...
Sahar Abubucker +3 more
doaj +1 more source
Impact of intestinal parasites on microbiota and cobalamin gene sequences: a pilot study
Parasites & Vectors, 2020 Background Approximately 30% of children worldwide are infected with gastrointestinal parasites. Depending on the species, parasites can disrupt intestinal bacterial microbiota affecting essential vitamin biosynthesis.
Rojelio Mejia +13 more
doaj +1 more source
Diagnostics, 2023 Background: Intestinal helminth parasites are potent stimulators of T helper type 2 (Th2) and regulatory Th3 anti-inflammatory immune responses, while human immunodeficiency virus (HIV) infections are activators of predominantly T helper type 1(Th1) pro-inflammatory responses.
Miranda N. Mpaka-Mbatha +6 more
openaire +3 more sources
Frontiers in Cellular and Infection Microbiology, 2021 As an adaption to their complex lifecycles, helminth parasites garner a unique repertoire of genes at different developmental stages with subtle regulatory mechanisms.
Yi Mu +3 more
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