Scientific Reports, 2022 Next-generation sequencing technologies have accelerated the pace of helminth DNA metabarcoding research, enabling species detection in bulk community samples.
Abigail Hui En Chan +7 more
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Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. [PDF]
PLoS Neglected Tropical Diseases, 2016 Helminth infections affect more than a third of the world's population. Despite very broad phylogenetic differences among helminth parasite species, a systemic Th2 host immune response is typically associated with long-term helminth infections, also ...
Guangyan Zhou +3 more
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PLoS Pathogens, 2021 Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection.
B Karina Montero +9 more
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HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization. [PDF]
PLoS ONE, 2011 A vast majority of the burden from neglected tropical diseases result from helminth infections (nematodes and platyhelminthes). Parasitic helminthes infect over 2 billion, exerting a high collective burden that rivals high-mortality conditions such as ...
Sahar Abubucker +3 more
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Impact of intestinal parasites on microbiota and cobalamin gene sequences: a pilot study
Parasites & Vectors, 2020 Background Approximately 30% of children worldwide are infected with gastrointestinal parasites. Depending on the species, parasites can disrupt intestinal bacterial microbiota affecting essential vitamin biosynthesis.
Rojelio Mejia +13 more
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Frontiers in Cellular and Infection Microbiology, 2021 As an adaption to their complex lifecycles, helminth parasites garner a unique repertoire of genes at different developmental stages with subtle regulatory mechanisms.
Yi Mu +3 more
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Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1. [PDF]
PLoS ONE, 2016 Helminth infections and allergic diseases are associated with IgE hyperresponsiveness but the genetics of this phenotype remain to be defined. Susceptibility to Ascaris lumbricoides infection and antibody levels to this helminth are associated with ...
Nathalie Acevedo +8 more
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B cell fate mapping reveals their contribution to the memory immune response against helminths
Frontiers in Immunology, 2022 An estimated quarter of the human world population is infected with gastrointestinal helminths causing major socioeconomic problems in endemic countries.
Paul Haase +5 more
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The landscape of human genes involved in the immune response to parasitic worms
BMC Evolutionary Biology, 2010 Background More than 2 billion individuals worldwide suffer from helminth infections. The highest parasite burdens occur in children and helminth infection during pregnancy is a risk factor for preterm delivery and reduced birth weight.
Fumagalli Matteo +6 more
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Plasticity of migrating CD1b+ and CD1b- lymph dendritic cells in the promotion of Th1, Th2 and Th17 in response to Salmonella and helminth secretions. [PDF]
PLoS ONE, 2013 Dendritic cells (DCs) are pivotal in the development of specific T-cell responses to control pathogens, as they govern both the initiation and the polarization of adaptive immunity.
Michel Olivier +4 more
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