Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio +12 more
wiley +1 more source
Nasal Retinal Degeneration Is a Feature of a Subset of CRX-Associated Retinopathies. [PDF]
Massengill MT +6 more
europepmc +1 more source
A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias [PDF]
Benoit, Yves +20 more
core
Microduplication 10q24.31 in a Spanish girl with scoliosis and myopathy:the critical role of LBX [PDF]
Calleja-Perez, Beatriz +9 more
core +2 more sources
Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo +6 more
wiley +1 more source
Identification and characterization of the <i>KNOTTED1-like</i> homeobox as an active regulator of leaf development in chickpea. [PDF]
Gutierrez N, Castro P, Rubio J, Die JV.
europepmc +1 more source
Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed
ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez +6 more
wiley +1 more source
Differential activity of transcription factors and neuronal effectors during the development of pikeperch brain. [PDF]
Symonová R +6 more
europepmc +1 more source
Tree growth response and adaptation to climate change and climate extremes: From canopy to stem
This review synthesizes the responses and adaptations of tree growth, including canopy phenology, intra‐annual wood formation dynamics, and annual stem growth, to climate change and climate extremes. It highlights key knowledge gaps for future research to support sustainable forest management and enhance forest carbon storage under ongoing climate ...
Feiyu Yang +8 more
wiley +1 more source
De novo stolon organogenesis in potato leaf callus elicited by Agrobacterium tumefaciens stimulus
Agrobacterium tumefaciens triggers stolon regeneration from potato leaf callus independent of T‐DNA insertion, suggesting a strategy to reprogram callus identity and expand the potential of tissue regeneration. ABSTRACT Plant cells can undergo cellular reprogramming, enabling pluripotent callus formation from excised leaves.
Seung Yong Shin +7 more
wiley +1 more source

