Results 71 to 80 of about 119,722 (304)

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Characterization of Rice Homeobox Genes, OsHOX22 and OsHOX24, and Over-expression of OsHOX24 in Transgenic Arabidopsis Suggest their Role in Abiotic Stress Response

Frontiers in Plant Science, 2016
Homeobox transcription factors are well known regulators of plant growth and development. In this study, we carried out functional analysis of two candidate stress-responsive HD-ZIP I class homeobox genes from rice, OsHOX22 and OsHOX24.
Annapurna eBhattacharjee, Jitendra Paul Khurana, Mukesh eJain, Mukesh eJain   +3 more
doaj   +1 more source

Immunohistochemical Evaluation of BARX1, DLX4, FOXE1, HOXB3, and MSX2 in Non-syndromic Cleft-affected Tissue

Acta Medica Lituanica, 2022
Background: Nonsyndromic craniofacial clefts are relatively common congenital malformations which could create a significant negative effect on the health status and life quality of affected individuals within the pediatric population.
Mārtiņš Vaivads, Ilze Akota, Māra Pilmane   +2 more
doaj   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

NKL homeobox gene activities in B-cell development and lymphomas. [PDF]

PLoS ONE, 2018
Homeobox genes encode transcription factors which regulate basic processes in development and cell differentiation. Several members of the NKL subclass are deregulated in T-cell progenitors and support leukemogenesis.
Stefan Nagel, Roderick A F MacLeod, Corinna Meyer, Maren Kaufmann, Hans G Drexler   +4 more
doaj   +1 more source

Expression of Distal-less, dachshund, and optomotor blind in Neanthes arenaceodentata (Annelida, Nereididae) does not support homology of appendage-forming mechanisms across the Bilateria [PDF]

, 2010
The similarity in the genetic regulation of arthropod and vertebrate appendage formation has been interpreted as the product of a plesiomorphic gene network that was primitively involved in bilaterian appendage development and co-opted to build ...
A Abzhanov, A Caracciolo, A Hejnol, A Hidalgo, A Horner, A Minelli, A Minelli, A Saudemont, A Schmidt-Rhaesa, A Wallberg, AD Chipman, AS Denes, B Hausdorf, B Mittmann, B Prud’homme, B Rhode, C Nielsen, Christopher J. Winchell, CJ Tabin, CJ Winchell, CL Hughes, CM Heuer, CM Heuer, CW Dunn, D Arendt, DA Dorsett, DA Dorsett, David K. Jacobs, DK Jacobs, DK Jacobs, DR Angelini, DR Angelini, DR Maddison, DW Golding, DW Stock, E Abouheif, EC Seaver, EC Seaver, F Ronquist, G Aspöck, G Balavoine, G Campbell, G Giribet, G Mardon, G Panganiban, G Panganiban, G Panganiban, G Scholtz, G Scholtz, G Scholtz, GA Wray, GF Striedter, GO Pflugfelder, GP Wagner, J Felsenstein, J Mallatt, J Mallatt, J Paps, J Paps, JD Thompson, JE Smith, JH Imai, JI Hamaker, JI Pueyo, JJ Gibson-Brown, Jonathan E. Valencia, K Bell, KJ Sepp, KL Hammond, KL Hammond, KS Pappu, L Maves, L Orrhage, L Orrhage, M Kulakova, M Qiu, M Schoppmeier, MJ Bastiani, MJ Telford, N Dray, N Gorfinkiel, N Shubin, N Shubin, N-M Prpic, N-M Prpic, N-M Prpic, N-M Prpic, NJ Strausfeld, NT Takaesu, P Dollé, R Abascal, R Desper, R Janssen, R Janssen, R Kirsch, R Tomer, RF Robledo, RJ Davis, S Candiani, S Guindon, S Nissim, SB Carroll, SF Altschul, SM Cohen, SM Cohen, SM Farris, SQ Irvine, SQ Irvine, SR Martini, T Bartolomaeus, T Kojima, TA Heanue, TA Williams, TH Bullock, W Arthur, W Sewell, W Westheide, WJ Brook, WJ Dickinson, X Yang, Y Boilly-Marer, Y Inoue, Y Inoue, Y Kida, Z Kozmik, Z Kozmik   +125 more
core   +4 more sources

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

Advanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao, Qianwen Lyu, Tinghao Zhang, Yupan Zou, Yue Xie, Dandan Yang, Cao Xu, Xiaozhen Huang   +7 more
wiley   +1 more source

Distal-less homeobox genes Dlx5/6 regulate Müllerian duct regression

Frontiers in Endocrinology, 2022
Dlx5 and Dlx6 encode distal-less homeodomain transcription factors that are present in the genome as a linked pair at a single locus. Dlx5 and Dlx6 have redundant roles in craniofacial, skeletal, and uterine development.
Rachel D. Mullen, Brice Bellessort, Giovanni Levi, Richard R. Behringer   +3 more
doaj   +1 more source

Finding New Cell Wall Regulatory Genes in Populus trichocarpa Using Multiple Lines of Evidence. [PDF]

, 2019
Understanding the regulatory network controlling cell wall biosynthesis is of great interest in Populus trichocarpa, both because of its status as a model woody perennial and its importance for lignocellulosic products.
Chen, Jin-Gui, DiFazio, Stephen, Dixon, Richard A, Furches, Anna, Gazolla, Joao Gabriel Felipe Machado, Jacobson, Daniel, Jones, Piet, Joubert, Wayne, Kainer, David, Large, Annabel, Macaya-Sanz, David, Martin, Madhavi Z, Ranjan, Priya, Rao, Xiaolan, Romero, Jonathon, Schmutz, Jeremy, Shah, Manesh, Sreedasyam, Avinash, Streich, Jared, Tschaplinski, Timothy J, Tuskan, Gerald A, Walker, Angelica M, Weighill, Deborah, Zhao, Nan   +23 more
core   +3 more sources

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source