Results 31 to 40 of about 5,788,302 (308)

Antigen Presentation Profiling Reveals Recognition of Lymphoma Immunoglobulin Neoantigens

Nature, 2017
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge.
M. Khodadoust, N. Olsson, Lisa E. Wagar, O. Haabeth, Binbin Chen, Kavya Swaminathan, Keith Rawson, C. Liu, D. Steiner, P. Lund, Samhita Rao, Lichao Zhang, C. Marceau, H. Stehr, Aaron M. Newman, D. Czerwinski, V. Carlton, M. Moorhead, M. Faham, H. Kohrt, J. Carette, Michael R. Green, Mark M. Davis, Ronald Levy, Joshua E. Elias, Ash A. Alizadeh   +25 more
semanticscholar   +1 more source

Expansion of the preimmune antibody repertoire by junctional diversity in Bos taurus. [PDF]

PLoS ONE, 2014
Cattle have a limited range of immunoglobulin genes which are further diversified by antigen independent somatic hypermutation in fetuses. Junctional diversity generated during somatic recombination contributes to antibody diversity but its relative ...
Jenni Liljavirta, Mikael Niku, Tiina Pessa-Morikawa, Anna Ekman, Antti Iivanainen   +4 more
doaj   +1 more source

Gene expression signatures associated with chronic endometritis revealed by RNA sequencing

Frontiers in Medicine, 2023
IntroductionChronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by the infiltration of plasma cells in the endometrial stroma.
Kyoko Oshina, Kyoko Oshina, Keiji Kuroda, Keiji Kuroda, Kazuhiko Nakabayashi, Junko Tomikawa, Mari Kitade, Rikikazu Sugiyama, Kenichiro Hata, Kenichiro Hata, Atsuo Itakura   +10 more
doaj   +1 more source

IgBLAST: an immunoglobulin variable domain sequence analysis tool

Nucleic Acids Res., 2013
The variable domain of an immunoglobulin (IG) sequence is encoded by multiple genes, including the variable (V) gene, the diversity (D) gene and the joining (J) gene.
Jian Ye, Ning Ma, Thomas L. Madden, J. Ostell   +3 more
semanticscholar   +1 more source

Target-selective homologous recombination cloning for high-throughput generation of monoclonal antibodies from single plasma cells

BMC Biotechnology, 2011
Background Molecular cloning of functional immunoglobulin genes from single plasma cells is one of the most promising technologies for the rapid development of monoclonal antibody drugs. However, the proper insertion of PCR-amplified immunoglobulin genes
Isobe Masaharu, Yoshioka Megumi, Kurosawa Nobuyuki   +2 more
doaj   +1 more source

Poorly Expressed Alleles of Several Human Immunoglobulin Heavy Chain Variable Genes are Common in the Human Population

Frontiers in Immunology, 2021
Extensive diversity has been identified in the human heavy chain immunoglobulin locus, including allelic variation, gene duplication, and insertion/deletion events. Several genes have been suggested to be deleted in many haplotypes.
Mats Ohlin
doaj   +1 more source

Physical map and one-megabase sequencing of the human immunoglobulin lambda locus

Genetics and Molecular Biology, 1998
The human immunoglobulin lambda (IGL) locus is located on chromosome 22q11.1-q11.2 and contains the genes responsible for the immunoglobulin lambda light chains. This locus was recently mapped (physical map) and its 1-Mb DNA totally sequenced.
Geraldo A.S. Passos Jr.
doaj   +1 more source

Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system

Life Science Alliance, 2021
In this study, Scheurer et al demonstrate that two genes encoding the effector domain of immunoglobulins are not only expressed by lymphocytes of the immune system but also by neurons in the central nervous system.
Louis Scheurer, Rebecca R Das Gupta, Annika Saebisch, Thomas Grampp, Dietmar Benke, Hanns Ulrich Zeilhofer, Hendrik Wildner   +6 more
doaj   +1 more source

Fungicidal activity of peptides encoded by immunoglobulin genes

Scientific Reports, 2017
Evidence from previous works disclosed the antimicrobial, antiviral, anti-tumour and/or immunomodulatory activity exerted, through different mechanisms of action, by peptides expressed in the complementarity-determining regions or even in the constant ...
Luciano Polonelli, Tecla Ciociola, Martina Sperindè, Laura Giovati, Tiziana D’Adda, Serena Galati, Luiz R. Travassos, Walter Magliani, Stefania Conti   +8 more
doaj   +1 more source

Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications

Frontiers in Immunology
Poultry immunoglobulin genes undergo diversification through homologous recombination (HR) and somatic hypermutation (SHM). Most animals share a similar system in immunoglobulin diversification, with the rare exception that human and murine ...
Hidetaka Seo, Kouji Hirota, Kunihiro Ohta   +2 more
doaj   +1 more source