Results 81 to 90 of about 357,256 (185)

Target-selective joint polymerase chain reaction: A robust and rapid method for high-throughput production of recombinant monoclonal antibodies from single cells

BMC Biotechnology, 2011
Background During the development of a therapeutic antibody, large numbers of monoclonal antibodies are required to screen for those that are best suited for the desired activity.
Isobe Masaharu, Kurosawa Nobuyuki, Yoshioka Megumi   +2 more
doaj   +1 more source

Ampk regulates IgD expression but not energy stress with B cell activation. [PDF]

, 2019
Ampk is an energy gatekeeper that responds to decreases in ATP by inhibiting energy-consuming anabolic processes and promoting energy-generating catabolic processes.
Ahsan, Fasih M, Braas, Daniel, Graeber, Thomas G, Hong, Jason S, Kim, Diane NH, Minasyan, Aspram, Teitell, Michael A, Ten Hoeve, Johanna, Waters, Lynnea R, Zangle, Thomas A   +9 more
core   +1 more source

Identification of a Carcinoembryonic Antigen Gene Family in the Rat [PDF]

, 1989
The existence of a carcinoembryonic antigen (CEA)-like gene family in rat has been demonstrated through isolation and sequencing of the N- terminal domain exons of presumably five discrete genes (rnCGM1-5).
Barnert, Sabine, Kleist, Sabine von, Kodelja, Vitam, Lucas, Kurt, Thompson, John A., Zimmermann, Wolfgang   +5 more
core  

Inferring processes underlying B-cell repertoire diversity

, 2015
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains.
Aleksandra M. Walczak, Curtis G. Callan, Dunn-Walters DK, Janeway C, Quentin Marcou, Shapiro GS, Shiokawa S, Stryer L, Thierry Mora, Yuval Elhanati, Zachary Sethna   +10 more
core   +1 more source

A system for precise analysis of transcription-regulating elements of immunoglobulin genes

BMC Biotechnology, 2005
Background Precise analysis of expression-regulating elements, such as enhancers and insulators, requires that they be tested under reproducible, isogenic conditions.
Berru Maribel, Collins Cathy, Cheng Emily Y, Shulman Marc J   +3 more
doaj   +1 more source

Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia. [PDF]

, 1993
B cell chronic lymphocytic leukemia (CLL) is a malignancy of the CD5+ B cells. Prior studies indicated that CLL B cells generally express immunoglobulin (Ig) VH and VL genes with little or no somatic mutations.
Kipps, TJ, Rassenti, LZ
core  

Immunoglobulin replacement therapies in inborn errors of immunity: a review

Frontiers in Pediatrics
Immunoglobulins (Ig) were used as a therapeutic modality for the first time in a patient with X-linked agammaglobulinemia in 1952 by Colonel Ogden Bruton, decades before the molecular mechanisms causing the disease were unraveled.
Archan Sil, Suprit Basu, Vibhu Joshi, Rakesh Kumar Pilania, Sangeetha Siniah, Deepti Suri, Amit Rawat, Surjit Singh   +7 more
doaj   +1 more source

Monitoring measurable residual disease in paediatric acute lymphoblastic leukaemia using immunoglobulin gene clonality based on next-generation sequencing

Cancer Cell International
Background Assessment of measurable residual disease (MRD) is an essential prognostic tool for B-lymphoblastic leukaemia (B-ALL). In this study, we evaluated the utility of next-generation sequencing (NGS)–based MRD assessment in real-world clinical ...
Won Kee Ahn, Kyunghee Yu, Hongkyung Kim, Seung-Tae Lee, Jong Rak Choi, Jung Woo Han, Chuhl Joo Lyu, Seungmin Hahn, Saeam Shin   +8 more
doaj   +1 more source

Determining cellular and biochemical function of a novel adhesion molecule in kidneys. [PDF]

, 2016
Acute kidney injury is an abrupt loss of kidney function that develops in short time with limited effective treatments other than kidney transplantation. We have identified TMIGD1 (Transmembrane immuno- globulin domain 1) as a novel receptor expressed in
Arafa, Emad
core   +1 more source

Novel rhesus macaque immunoglobulin germline genes identified by three sequencing approaches

Frontiers in Immunology
IntroductionRhesus macaques have long been a focus of research for understanding immune responses to human pathogens due to their close phylogenetic relationship with humans.
Yicheng Guo, Yicheng Guo, Eric Waltari, Hong Lu, Hong Lu, Zizhang Sheng, Zizhang Sheng, Xueling Wu, Xueling Wu   +8 more
doaj   +1 more source