Results 61 to 70 of about 234,036 (207)

The Carcinoembryonic Antigen Gene Family [PDF]

, 1988
The molecular cloning of carcinoembryonic antigen (CEA) and several cross-reacting antigens reveals a basic domain structure for the whole family, which shows structural similarities to the immunoglobulin superfamily.
Zimmermann, Wolfgang, Thompson, John A.
core  

Germline immunoglobulin genes: disease susceptibility genes hidden in plain sight? [PDF]

, 2020
Immunoglobulin genes are rarely considered as disease susceptibility genes despite their obvious and central contributions to immune function. This appears to be a consequence of historical views on antibody repertoire formation that no longer stand, and
Watson, C.T., Lees, William, Yaari, G., Collins, A.M., Shepherd, Adrian J.   +4 more
core   +1 more source

Immunoglobulin germline reference sequences enable investigations and reveal insights into bat-specific immunity

iScience
Summary: We generated a highly contiguous, annotated genome of the Jamaican fruit bat, Artibeus jamaicensis, including annotated germline immunoglobulin heavy-chain (IGH) and light-chain lambda (IGL) loci to understand bat B cell receptor repertoires ...
Ashley B. Reers, Shijun Zhan, Taylor Pursell, Clara Reasoner, Natasha Hodges, Tanya M. Lama, Tony Schountz, Hannah K. Frank   +7 more
doaj   +1 more source

The properties of CpG islands in the putative promoter regions of human immunoglobulin (Ig) genes

, 2005
CpG island is a GC-rich motif occurred in gene promoter region, which can play important roles in gene silencing and imprinting. Here, we present a set of discriminant functions that can recognize the structural and compositional features of CpG islands ...
Chen, Rong, Guang B. Liu, John D. Pettigrew, Zhao, Kong-Nan, Ya F. Jiang, Liu, Guang B., Rong Chen, Jiang, Ya F., Kong-Nan Zhao, Yan, Hong, Pettigrew, John D., Hong Yan   +11 more
core   +1 more source

Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis

, 2009
Objectives: To assess the possible association of killer immunoglobulin-like receptor (KIR) genes, specifically KIR3DL1, KIR3DS1 and KIR3DL2, with ankylosing spondylitis (AS).
Pointon, JJ, Farrar, C, Sun, JY, Harvey, D, Brown, M A, Sleator, C, Sleator, C., Middleton, D, Brown, MA, Meenagh, A, Wordsworth, BP, Meenagh, A., Senitzer, D., Pointon, J. J., Senitzer, D, Wordsworth, B. P., Farrar, C., Sun, J. Y., Middleton, D., Wordsworth, Bryan, Harvey, D.   +20 more
core   +1 more source

A novel soluble immune-type receptor (SITR) in teleost fish: carp SITR is involved in the nitric oxide-mediated response to a protozoan parasite

, 2011
Background- The innate immune system relies upon a wide range of germ-line encoded receptors including a large number of immunoglobulin superfamily (IgSF) receptors.
Wiegertjes Geert F., Geert Raes, Schijns Virgil E. J. C., Ghassabeh, G.H., Ghassabeh, Gholamreza H., Huub F. J. Savelkoul, Savelkoul, H.F.J., Geert F Wiegertjes, Savelkoul Huub F. J., Virgil E J C Schijns, Ghassabeh Gholamreza H., Gholamreza H. Ghassabeh, Maria J. S. L. Pontes, Ribeiro, Carla M. S., Wiegertjes, G.F., Raes, Geert, Savelkoul, Huub F. J., Carla M S Ribeiro, Schijns, V.E.J.C., Steve Bird, Raes, G., Maria J S L Pontes, Huub F J Savelkoul, Pontes, Maria J. S. L., Schijns, Virgil E. J. C., Virgil E. J. C. Schijns, Raes Geert, Ribeiro, C.M.S., Wiegertjes, Geert F., Bird Steve, Gholamreza H Ghassabeh, Carla M. S. Ribeiro, Pontes, M.J.S.L., Ribeiro Carla M. S., Pontes Maria J. S. L., Bird, Steve, Geert F. Wiegertjes   +36 more
core   +1 more source

Challenges for the immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era

ImmunoInformatics
For over thirty years, an approach to the nomenclatures of human immunoglobulin (IG) and T cell receptor (TR) genes has operated successfully and has been widely supported by the research community. The principles behind the human nomenclatures were then
Andrew M. Collins, Corey T. Watson, Henk-Jan van den Ham, Luc Teyton, Elisa Rosati, Yana Safonova   +5 more
doaj   +1 more source

Immunoglobulin genes and diversity: what we have learned from domestic animals

Journal of Animal Science and Biotechnology, 2012
This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α ...
Sun Yi, Liu Zhancai, Ren Liming, Wei Zhiguo, Wang Ping, Li Ning, Zhao Yaofeng   +6 more
doaj   +1 more source

EXPRESSION OF A FUNCTIONAL CHIMERIC lg-MHC CLASS II PROTEIN [PDF]

, 1992
composed of the a- and ß-chains of the MHC class I1 I-E molecule fused to antibody V regions derived from anti-human CD4 mAb MT310. Expression vectors were constructed containing the functional, rearranged gene segments coding for the V region domains of
Zwirner, Jörg, Widera, Georg, Rieber, Ernst Peter, Karlsson, Lars, Peterson, Per A., Becker, Andrea, Weissenhorn, Winfried, Weiss, Elisabeth H., Riethmüller, Gert   +8 more
core   +1 more source

Organisation of the equine immunoglobulin constant heavy chain genes. II. Equine cgamma genes.

, 1998
The number of immunoglobulin G constant heavy chain genes (cgamma genes) varies broadly among mammalian species, reflecting structural and functional differences between expressed immunoglobulin G (IgG) isotypes and allotypes.
Overesch, Gudrun, Leibold, W, Radbruch, A, Wagner, B   +3 more
core