Results 71 to 80 of about 234,036 (207)

Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system

Nature Communications, 2016
CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up ...
Taek-Chin Cheong, Mara Compagno, Roberto Chiarle   +2 more
doaj   +1 more source

The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'

, 2006
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Snyder, Lori A. S., Snyder, Lori AS, Snyder, LA, Saunders Nigel J, Snyder, LAS, Saunders, Nigel, Lori AS Snyder, Saunders, NJ, Nigel J Saunders, Saunders, Nigel J., Snyder Lori AS   +10 more
core   +1 more source

Lamarck and immunity: Somatic and germline evolution of antibody genes

, 2009
Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus
Steele, E.J.
core  

Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes

Frontiers in Immunology, 2016
In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ag) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY
Thiago Detanico, Matthew Phillips, Lawrence J. Wysocki, Lawrence J. Wysocki   +3 more
doaj   +1 more source

Differential expression of CD 180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes

, 2005
We have studied the surface expression of the Toll-like receptor family member CD180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD180 expression, but this was always less than that expressed
Jewell, A.P., Clark, E.A., P. Ely, T. J. Hamblin, Wallace, P., Duke, V., Heelan, B., A. P. Jewell, Hamblin, T.J., B. Heelan, Yong, K.L., P. Wallace, Nathwani, A., Porakishvili, N., P. Y. Youinou, Youinou, P.Y., V. Duke, Lydyard, P.M., N. Porakishvili, Ely, P., N. Kulikova, K. Yong, A. Nathwani, Yong, K., E. A. Clark, Kulikova, N., P. M. Lydyard   +26 more
core   +1 more source

Dissecting the roles of histone deacetylase 1 and 2 in the hematopoietic system [PDF]

, 2008
Reversible histone acetylation on lysine residues has been intensively studied as an epigenetic mark for gene activation in a variety of eukaryotes. Histone deacetylases (HDACs) act to repress gene expression by removing acetyl groups from histones and ...
Yamaguchi, Teppei
core   +1 more source

Associação de genes KIR ao lúpus eritematoso sistêmico em Santa Catarina [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis ...
Coelho, Cíntia Callegari
core  

Virus-neutralizing monoclonal antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis [PDF]

, 2001
Neutralizing antibodies represent a major host defense mechanism against viral infections. In mammals, passive immunity is provided by neutralizing antibodies passed to the offspring via the placenta or the milk as immunoglobulin G and secreted ...
Pewe, L, John Webster, Whitelaw, C B, Andreas F. Kolb, Perlman, S, Siddell, S G, Stanley Perlman, C. Bruce A. Whitelaw, Stuart G. Siddell, Webster, J, Kolb, A F, Lecia Pewe   +11 more
core   +1 more source

A Proposed New Nomenclature for the Immunoglobulin Genes of Mus musculus

Frontiers in Immunology, 2019
Mammalian immunoglobulin (IG) genes are found in complex loci that contain hundreds of highly similar pseudogenes, functional genes and repetitive elements, which has made their investigation particularly challenging.
Christian E. Busse, Katherine J. L. Jackson, Corey T. Watson, Andrew M. Collins   +3 more
doaj   +1 more source

T cell receptor and immunoglobulin genes in hematologic malignancies

, 1990
In this review, we discuss the structure, organization and activation of the immunoglobulin (Ig) and T cell receptor (TCR) genes and the use of DNA probes derived from these genes as tools to determine clonality and cell lineage in hemopoietic ...
Griesser, Henrik, Mak, Tak W., Reis, Marciano D.   +2 more
core   +1 more source