Results 161 to 170 of about 697 (217)

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, EarlyView.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

iMeta, EarlyView.
Early‐pregnancy microbiome and lipidome profiling identified a microbiome‐glycosphingolipid axis associated with later gestational diabetes mellitus (GDM) risk. In the prospective pregnancy cohort, women who later developed GDM showed altered gut microbial composition, enriched microbial lipid biosynthesis pathways, and broad plasma lipidomic changes ...
Zhonghan Sun, Chang He, Xiaonan Ma, Ping Wu, Tianlei Wang, Jiaying Yuan, Yanni Pu, Xiaofeng Zhou, Zhendong Mei, Huiling Song, Yetong Wang, Haiyan Yue, Yuanqing Fu, Jusheng Zheng, An Pan, Da Chen, Shangyu Hong, Xiong‐Fei Pan, Yan Zheng   +18 more
wiley   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

Annual Review of Immunology, 1996
▪ Abstract  Precise regulation of major histocompatibility complex class II (MHC-II) gene expression plays a crucial role in the control of the immune response. A major breakthrough in the elucidation of the molecular mechanisms involved in MHC-II regulation has recently come from the study of patients that suffer from a primary immunodeficiency ...
B Mach, Walter Reith, Viktor Steimle
exaly   +5 more sources

Transcriptional regulation of MHC class II genes

International Journal of Clinical & Laboratory Research, 1995
MHC class II molecules play a fundamental role in the homeostasis of the immune response, functioning as receptors for antigenic peptides to be presented to regulatory T cells. Both quantitative and qualitative alterations in the expression of these molecules on the cell surface dramatically affect the onset of the immune response, and may be the basis
SARTORIS, Silvia, R. S. Accolla
openaire   +3 more sources

Class II Mhc Genes in Rodent Evolution

Immunological Reviews, 1990
Article synthese sur l'evolution moleculaire des genes d'histocompatibilite de classe II chez les ...
F, Figueroa, J, Gutknecht, H, Tichy, J, Klein   +3 more
openaire   +2 more sources

Mutation of RFXAP, a Regulator of MHC Class II Genes, in Primary MHC Class II Deficiency

New England Journal of Medicine, 1997
Major-histocompatibility-complex (MHC) class II deficiency is an autosomal recessive primary immunodeficiency disease in which MHC class II molecules are absent. It is a genetically heterogeneous disease of gene regulation resulting from defects in several transactivating genes that regulate the expression of MHC class II genes.
Villard, Jean, Lisowska-Grospierre, B., van den Elsen, P., Fischer, A., Reith, Walter, Mach, Bernard   +5 more
openaire   +4 more sources

Regulation of MHC class II gene expression by the class II transactivator

Nature Reviews Immunology, 2005
MHC class II molecules are pivotal for the adaptive immune system, because they guide the development and activation of CD4+ T helper cells. Fulfilling these functions requires that the genes encoding MHC class II molecules are transcribed according to a strict cell-type-specific and quantitatively modulated pattern.
Reith, Walter, LeibundGut-Landmann, Salomé, Waldburger, Jean-Marc   +2 more
openaire   +4 more sources

The class II genes of the rat MHC.

The Journal of Immunology, 1989
Abstract Genes that encode class II Ag from the MHC of the rat, the RT1 region, have been isolated as a series of cosmid clones. The cosmids define two clusters, each of which contains three identifiable sequences; one homologous to alpha-chain and two to beta-chain genes.
A G, Diamond, L E, Hood, J C, Howard, M, Windle, A, Winoto   +4 more
openaire   +2 more sources

The enhancer in an MHC class II gene, in vitro and in mouso

Biochimie, 1988
The E alpha class II gene of the major histocompatibility complex is expressed in a variety of immunocompetent cells. Part of the control of tissue-specific expression is mediated by a block of sequences found far upstream of the transcriptional startsite; this stretch is necessary for expression in the B lymphocytes of transgenic mice, but largely ...
P, Gerber, G, Lang, A, Dorn, J, Fehling, G, Garcin, W, Koch, C, Waltzinger, C, Benoist, D, Mathis   +8 more
openaire   +2 more sources