Results 181 to 190 of about 697 (217)

Immunosenescence of macrophages: reduced MHC class II gene expression

Experimental Gerontology, 2002
In order to determine the effect of aging on macrophages, we produced bone marrow-derived macrophages in vitro from young and aged mice. We analyzed the effect of aging on the genomic expression of macrophages in these conditions, without the influence of other cell types that may be affected by aging.
Carmen, Herrero, Carlos, Sebastián, Laura, Marqués, Mònica, Comalada, Jordi, Xaus, Annabel F, Valledor, Jorge, Lloberas, Antonio, Celada   +7 more
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The Generation and Maintenance of MHC Class II Gene Polymorphism in Rodents

Immunological Reviews, 1990
Etude de la diversification du gene Aβ du site de fixation de l'antigene dans la molecule de classe II du systeme d'histocompatibilite majeur des ...
E K, Wakeland, S, Boehme, J X, She
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MHC class II genes in European wolves: a comparison with dogs

Immunogenetics, 2002
The genome of the grey wolf, one of the most widely distributed land mammal species, has been subjected to both stochastic factors, including biogeographical subdivision and population fragmentation, and strong selection during the domestication of the dog.
Seddon, JM, Ellegren, H
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Functional expression of a transfected murine class II MHC gene

Nature, 1983
The activation of T helper lymphocytes involves the recognition of class II major histocompatibility complex antigens, which are dimeric glycoproteins (of subunit composition A alpha A beta or E alpha E beta) expressed on the surfaces of macrophages and B lymphocytes.
R N, Germain, M A, Norcross, D H, Margulies   +2 more
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Negative regulation of MHC class II gene expression by CXCR4

Experimental Hematology, 2006
CXCR4 is overexpressed in 23 types of cancers of both hematopoietic and nonhematopoietic origin. Based on the known role of CXCR4 and its ligand CXCL12 in homing of hematopoietic cells, CXCR4 is likely to play a role in metastasis. We have initiated a study aimed at dissecting additional functions of CXCR4 in cancer cells, particularly in relation to ...
Carol, Sheridan, Miral, Sadaria, Poornima, Bhat-Nakshatri, Robert, Goulet, Howard J, Edenberg, Brian P, McCarthy, Cheong-Hee, Chang, Edward F, Srour, Harikrishna, Nakshatri   +8 more
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The nucleotide sequence of the sheep MHC class II DNA gene

Immunogenetics, 1995
The human MHC class II DNA gene was identified and sequenced by Trowsdale and Kelly. When a molecular map of the HLA-D region became available, it was shown that the HLA-DNA gene was unusual in not having a B gene partner situated within a few kilobases (kb), the nearest B gene being HLA-DPB1.
H, Wright, J, Redmond, F, Wright, K T, Ballingall   +3 more
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Polimorphism of bovine MHC class II genes

1994
Polymorphism of the bovine DRB, DQA, DQB, DYA, DOB and DIB genes was investigated using restriction fragment length polymorphism (RFLP) analysis, isoelectric focusing (IEF), class II serology and polymerase chain reaction (PCR) based typing techniques. The simultaneous application of multiple typing techniques and the characterization of multiple genes
C. J. Davies, I. Joosten, L. Andersson, M. A. Arriens, D. Bernoco, B. Bissumbhar, G. Byrns, M. J. T. van Eijk, B. Kristensen, H. A. Lewin, S. Mikko, A. L. G. Morgan, N. E. Muggli Cockett, P. R. Nilsson, R. A. Oliver, C. A. Park, J. J. Van Der Poel, M. Polli, R. L. Spooner, J. A. Stewart   +19 more
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Regulation of MHC class II gene transcription.

Current opinion in immunology, 1991
The transcriptional regulation of MHC class II genes involves the interaction of DNA-binding proteins with specific DNA sequences. The cis elements of the promoter region have now been well delineated functionally, while the proteins that interact with these elements are just beginning to be identified and their functional importance assessed.
C J, Kara, L H, Glimcher
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The evolution of MHC class II genes

Immunology Today, 1986
F, Figueroa, J, Klein
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Mhc Class II Genes of Nonhuman Primates

1997
In humans the HLA-D region was originally discovered by use of the mixed lymphocyte culture (MLC) test. This assay is based on coculturing lymphocyte suspensions of two unrelated individuals and actually measures the proliferative capacity of T lymphocytes.
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