Results 171 to 180 of about 697 (217)

Transcriptional Regulation of MHC Class II Gene Expression: Are MHC Class II Genes Coordinately Regulated?

1990
MHC (Major Histocompatibility Complex) Class II antigens are polymorphic cell surface glycoproteins which bind foreign antigens and form a complex which is recognized by T lymphocyte antigen receptors. Presentation of foreign antigens by self MHC molecules to T cells triggers antigen-specific responses in the immune system.
H.-C. Liou, L. B. Ivashkiv, C. J. Kara, L. H. Glimcher   +3 more
openaire   +1 more source

Role of MHC Class II Genes in the pathogenesis of pemphigoid

Autoimmunity Reviews, 2011
Pemphigoid (Pg) is an autoimmune subepidermal blistering disease that affects the elderly population. The phenotype can be Bullous Pemphigoid (BP), which primarily involves the skin, or Mucous Membrane Pemphigoid (MMP), which primarily involves mucus membranes. Ocular Cicatricial Pemphigoid (OCP) and Oral Pemphigoid (OP) are subsets of MMP.
L R, Zakka, P, Reche, A R, Ahmed
openaire   +2 more sources

Regulation of transcription of MHC class II genes

Current Opinion in Immunology, 1997
Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II ...
openaire   +2 more sources

MHC Class II and Related Genes

2008
Abstract The MHC class II antigen-processing pathway plays a central role in the adaptive immune response to microbial pathogens as the mechanism through which ligands are generated for recognition by CD4+ helper T cells. CD4+ helper T cells are activated by recognition of short peptide antigens stably bound to MHC class II molecules ...
Janet M McNicholl, Peter E Jensen, Jeremy M Boss   +2 more
openaire   +1 more source

A model for the transcriptional regulation of MHC class II genes

Immunology Today, 1987
The analysis of la antigens has focused primarily on their structure and function. However, the quantitative differences in immune response gene expression are equally important, since variation of cell surface la influences immunoregulation and the expression of immunologically mediated disease.
K E, Sullivan, A F, Calman, M, Nakanishi, S Y, Tsang, Y, Wang, B M, Peterlin   +5 more
openaire   +2 more sources

The MHC class I genes of the rhesus monkey. Different evolutionary histories of MHC class I and II genes in primates

The Journal of Immunology, 1996
Abstract Homologues of the human HLA-A and -B MHC class I loci have been found in great apes and Old World primates suggesting that these two loci have existed for at least 30 million years. The C locus, however, shows some sequence similarity to the B locus and has been found only in gorillas, chimpanzees, and humans.
J E, Boyson, C, Shufflebotham, L F, Cadavid, J A, Urvater, L A, Knapp, A L, Hughes, D I, Watkins   +6 more
openaire   +2 more sources

Structure and function of genes in the MHC class II region

Current Opinion in Immunology, 1993
Genes required for antigen processing map to the MHC class II region. For the endogenous (class I) antigen processing pathway, many hypotheses concerning the structure and function of the corresponding gene products have been verified during the past year. The identity of the gene(s) involved in the exogenous (class II) pathway remains to be determined.
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MHC class II A genes in the channel catfish (Ictalurus punctatus)

Developmental & Comparative Immunology, 1997
Two different cDNA sequences for major histocompatibility complex (MHC) class II beta chains from the channel catfish (Ictalurus punctatus) have been identified. Homology between these sequences and those previously identified as MHC class II B genes in other teleosts suggests they represent alleles of the DAB locus.
U B, Godwin, M, Flores, S, Quiniou, M R, Wilson, N W, Miller, L W, Clem, T J, McConnell   +6 more
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Defective MHC class II expression in an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene

Immunogenetics, 2000
MHC class II deficiency patients are mutated for transcription factors that regulate the expression of major histocompatibility complex (MHC) class II genes. Four complementation groups (A-D) are defined and the gene defective in group A has been shown to encode the MHC class II transactivator (CIITA).
A, Peijnenburg, R, Van den Berg, M J, Van Eggermond, O, Sanal, J M, Vossen, A M, Lennon, C, Alcaïde-Loridan, P J, Van den Elsen   +7 more
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Combined immunodeficiency with abnormal expression of MHC class II genes

Clinical Immunology and Immunopathology, 1989
The MHC class II CID represents an example of immunodeficiency in which the defect in expression of membrane glycoproteins leads to abnormal cell to cell interactions and thus to abnormal immune responses. It represents an interesting model which confirms the importance of MHC molecules in all immune responses to foreign antigens.
C, Griscelli, B, Lisowska-Grospierre, F, Le Deist, A, Durandy, A, Marcadet, A, Fischer, C, de Preval, B, Mach   +7 more
openaire   +2 more sources