Results 211 to 220 of about 97,657 (267)

Oligodendroglia as Active Immunomodulators in Demyelinating Diseases. [PDF]

Neurosci Bull
Park J, Cheon SY, Barman B, Guo F.
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Transcriptional regulation of MHC class II genes

International Journal of Clinical & Laboratory Research, 1995
MHC class II molecules play a fundamental role in the homeostasis of the immune response, functioning as receptors for antigenic peptides to be presented to regulatory T cells. Both quantitative and qualitative alterations in the expression of these molecules on the cell surface dramatically affect the onset of the immune response, and may be the basis
SARTORIS, Silvia, R. S. Accolla
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Class II Mhc Genes in Rodent Evolution

Immunological Reviews, 1990
Article synthese sur l'evolution moleculaire des genes d'histocompatibilite de classe II chez les ...
F, Figueroa, J, Gutknecht, H, Tichy, J, Klein   +3 more
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Mutation of RFXAP, a Regulator of MHC Class II Genes, in Primary MHC Class II Deficiency

New England Journal of Medicine, 1997
Major-histocompatibility-complex (MHC) class II deficiency is an autosomal recessive primary immunodeficiency disease in which MHC class II molecules are absent. It is a genetically heterogeneous disease of gene regulation resulting from defects in several transactivating genes that regulate the expression of MHC class II genes.
Villard, Jean, Lisowska-Grospierre, B., van den Elsen, P., Fischer, A., Reith, Walter, Mach, Bernard   +5 more
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Regulation of MHC class II gene expression by the class II transactivator

Nature Reviews Immunology, 2005
MHC class II molecules are pivotal for the adaptive immune system, because they guide the development and activation of CD4+ T helper cells. Fulfilling these functions requires that the genes encoding MHC class II molecules are transcribed according to a strict cell-type-specific and quantitatively modulated pattern.
Reith, Walter, LeibundGut-Landmann, Salomé, Waldburger, Jean-Marc   +2 more
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The class II genes of the rat MHC.

The Journal of Immunology, 1989
Abstract Genes that encode class II Ag from the MHC of the rat, the RT1 region, have been isolated as a series of cosmid clones. The cosmids define two clusters, each of which contains three identifiable sequences; one homologous to alpha-chain and two to beta-chain genes.
A G, Diamond, L E, Hood, J C, Howard, M, Windle, A, Winoto   +4 more
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Role of MHC Class II Genes in the pathogenesis of pemphigoid

Autoimmunity Reviews, 2011
Pemphigoid (Pg) is an autoimmune subepidermal blistering disease that affects the elderly population. The phenotype can be Bullous Pemphigoid (BP), which primarily involves the skin, or Mucous Membrane Pemphigoid (MMP), which primarily involves mucus membranes. Ocular Cicatricial Pemphigoid (OCP) and Oral Pemphigoid (OP) are subsets of MMP.
L R, Zakka, P, Reche, A R, Ahmed
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Transcriptional Regulation of MHC Class II Gene Expression: Are MHC Class II Genes Coordinately Regulated?

1990
MHC (Major Histocompatibility Complex) Class II antigens are polymorphic cell surface glycoproteins which bind foreign antigens and form a complex which is recognized by T lymphocyte antigen receptors. Presentation of foreign antigens by self MHC molecules to T cells triggers antigen-specific responses in the immune system.
H.-C. Liou, L. B. Ivashkiv, C. J. Kara, L. H. Glimcher   +3 more
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The enhancer in an MHC class II gene, in vitro and in mouso

Biochimie, 1988
The E alpha class II gene of the major histocompatibility complex is expressed in a variety of immunocompetent cells. Part of the control of tissue-specific expression is mediated by a block of sequences found far upstream of the transcriptional startsite; this stretch is necessary for expression in the B lymphocytes of transgenic mice, but largely ...
P, Gerber, G, Lang, A, Dorn, J, Fehling, G, Garcin, W, Koch, C, Waltzinger, C, Benoist, D, Mathis   +8 more
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Regulation of transcription of MHC class II genes

Current Opinion in Immunology, 1997
Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II ...
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