Results 221 to 230 of about 97,657 (267)

MHC Class II and Related Genes

2008
Abstract The MHC class II antigen-processing pathway plays a central role in the adaptive immune response to microbial pathogens as the mechanism through which ligands are generated for recognition by CD4+ helper T cells. CD4+ helper T cells are activated by recognition of short peptide antigens stably bound to MHC class II molecules ...
Janet M McNicholl, Peter E Jensen, Jeremy M Boss   +2 more
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A model for the transcriptional regulation of MHC class II genes

Immunology Today, 1987
The analysis of la antigens has focused primarily on their structure and function. However, the quantitative differences in immune response gene expression are equally important, since variation of cell surface la influences immunoregulation and the expression of immunologically mediated disease.
K E, Sullivan, A F, Calman, M, Nakanishi, S Y, Tsang, Y, Wang, B M, Peterlin   +5 more
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REGULATION OF MHC CLASS II GENES: Lessons from a Disease

Annual Review of Immunology, 1996
▪ Abstract  Precise regulation of major histocompatibility complex class II (MHC-II) gene expression plays a crucial role in the control of the immune response. A major breakthrough in the elucidation of the molecular mechanisms involved in MHC-II regulation has recently come from the study of patients that suffer from a primary immunodeficiency ...
Mach, Bernard, Steimle, Viktor, Martinez-Soria, Eduardo, Reith, Walter   +3 more
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The MHC class I genes of the rhesus monkey. Different evolutionary histories of MHC class I and II genes in primates

The Journal of Immunology, 1996
Abstract Homologues of the human HLA-A and -B MHC class I loci have been found in great apes and Old World primates suggesting that these two loci have existed for at least 30 million years. The C locus, however, shows some sequence similarity to the B locus and has been found only in gorillas, chimpanzees, and humans.
J E, Boyson, C, Shufflebotham, L F, Cadavid, J A, Urvater, L A, Knapp, A L, Hughes, D I, Watkins   +6 more
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Structure and function of genes in the MHC class II region

Current Opinion in Immunology, 1993
Genes required for antigen processing map to the MHC class II region. For the endogenous (class I) antigen processing pathway, many hypotheses concerning the structure and function of the corresponding gene products have been verified during the past year. The identity of the gene(s) involved in the exogenous (class II) pathway remains to be determined.
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MHC class II A genes in the channel catfish (Ictalurus punctatus)

Developmental & Comparative Immunology, 1997
Two different cDNA sequences for major histocompatibility complex (MHC) class II beta chains from the channel catfish (Ictalurus punctatus) have been identified. Homology between these sequences and those previously identified as MHC class II B genes in other teleosts suggests they represent alleles of the DAB locus.
U B, Godwin, M, Flores, S, Quiniou, M R, Wilson, N W, Miller, L W, Clem, T J, McConnell   +6 more
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Defective MHC class II expression in an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene

Immunogenetics, 2000
MHC class II deficiency patients are mutated for transcription factors that regulate the expression of major histocompatibility complex (MHC) class II genes. Four complementation groups (A-D) are defined and the gene defective in group A has been shown to encode the MHC class II transactivator (CIITA).
A, Peijnenburg, R, Van den Berg, M J, Van Eggermond, O, Sanal, J M, Vossen, A M, Lennon, C, Alcaïde-Loridan, P J, Van den Elsen   +7 more
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Immunosenescence of macrophages: reduced MHC class II gene expression

Experimental Gerontology, 2002
In order to determine the effect of aging on macrophages, we produced bone marrow-derived macrophages in vitro from young and aged mice. We analyzed the effect of aging on the genomic expression of macrophages in these conditions, without the influence of other cell types that may be affected by aging.
Carmen, Herrero, Carlos, Sebastián, Laura, Marqués, Mònica, Comalada, Jordi, Xaus, Annabel F, Valledor, Jorge, Lloberas, Antonio, Celada   +7 more
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The Generation and Maintenance of MHC Class II Gene Polymorphism in Rodents

Immunological Reviews, 1990
Etude de la diversification du gene Aβ du site de fixation de l'antigene dans la molecule de classe II du systeme d'histocompatibilite majeur des ...
E K, Wakeland, S, Boehme, J X, She
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MHC class II genes in European wolves: a comparison with dogs

Immunogenetics, 2002
The genome of the grey wolf, one of the most widely distributed land mammal species, has been subjected to both stochastic factors, including biogeographical subdivision and population fragmentation, and strong selection during the domestication of the dog.
Seddon, JM, Ellegren, H
openaire   +5 more sources