Results 231 to 240 of about 97,657 (267)

Functional expression of a transfected murine class II MHC gene

Nature, 1983
The activation of T helper lymphocytes involves the recognition of class II major histocompatibility complex antigens, which are dimeric glycoproteins (of subunit composition A alpha A beta or E alpha E beta) expressed on the surfaces of macrophages and B lymphocytes.
R N, Germain, M A, Norcross, D H, Margulies   +2 more
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Negative regulation of MHC class II gene expression by CXCR4

Experimental Hematology, 2006
CXCR4 is overexpressed in 23 types of cancers of both hematopoietic and nonhematopoietic origin. Based on the known role of CXCR4 and its ligand CXCL12 in homing of hematopoietic cells, CXCR4 is likely to play a role in metastasis. We have initiated a study aimed at dissecting additional functions of CXCR4 in cancer cells, particularly in relation to ...
Carol, Sheridan, Miral, Sadaria, Poornima, Bhat-Nakshatri, Robert, Goulet, Howard J, Edenberg, Brian P, McCarthy, Cheong-Hee, Chang, Edward F, Srour, Harikrishna, Nakshatri   +8 more
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Combined immunodeficiency with abnormal expression of MHC class II genes

Clinical Immunology and Immunopathology, 1989
The MHC class II CID represents an example of immunodeficiency in which the defect in expression of membrane glycoproteins leads to abnormal cell to cell interactions and thus to abnormal immune responses. It represents an interesting model which confirms the importance of MHC molecules in all immune responses to foreign antigens.
C, Griscelli, B, Lisowska-Grospierre, F, Le Deist, A, Durandy, A, Marcadet, A, Fischer, C, de Preval, B, Mach   +7 more
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Hypomethylation of MHC class II Eb gene is associated with expression

Immunogenetics, 1992
Methylation patterns in the major histocompatibility complex (MHC) class II Eb locus have been analyzed in cell lines representative of different cell types; in particular those with phenotypes found at various stages of B cell development. A series of variant B cell lymphoma lines which serves as a model in which to investigate mechanisms regulating ...
T, Scholl, A, Pitcock, B, Jones
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The nucleotide sequence of the sheep MHC class II DNA gene

Immunogenetics, 1995
The human MHC class II DNA gene was identified and sequenced by Trowsdale and Kelly. When a molecular map of the HLA-D region became available, it was shown that the HLA-DNA gene was unusual in not having a B gene partner situated within a few kilobases (kb), the nearest B gene being HLA-DPB1.
H, Wright, J, Redmond, F, Wright, K T, Ballingall   +3 more
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Characterization of the MHC class II α-chain gene in ducks

Immunogenetics, 2011
In humans, classical MHC class II molecules include DQ, DR, and DP, which are similar in structure but consist of distinct α- and β-chains. The genes encoding these molecules are all located in the MHC class II gene region. In non-mammalian vertebrates such as chickens, only a single class II α-chain gene corresponding to the human DRA has been ...
Liming, Ren, Zhi, Yang, Tao, Wang, Yi, Sun, Ying, Guo, Ziding, Zhang, Jing, Fei, Yonghua, Bao, Tong, Qin, Jing, Wang, Yinhua, Huang, Xiaoxiang, Hu, Yaofeng, Zhao, Ning, Li   +13 more
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Polimorphism of bovine MHC class II genes

1994
Polymorphism of the bovine DRB, DQA, DQB, DYA, DOB and DIB genes was investigated using restriction fragment length polymorphism (RFLP) analysis, isoelectric focusing (IEF), class II serology and polymerase chain reaction (PCR) based typing techniques. The simultaneous application of multiple typing techniques and the characterization of multiple genes
C. J. Davies, I. Joosten, L. Andersson, M. A. Arriens, D. Bernoco, B. Bissumbhar, G. Byrns, M. J. T. van Eijk, B. Kristensen, H. A. Lewin, S. Mikko, A. L. G. Morgan, N. E. Muggli Cockett, P. R. Nilsson, R. A. Oliver, C. A. Park, J. J. Van Der Poel, M. Polli, R. L. Spooner, J. A. Stewart   +19 more
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Regulation of MHC class II gene transcription.

Current opinion in immunology, 1991
The transcriptional regulation of MHC class II genes involves the interaction of DNA-binding proteins with specific DNA sequences. The cis elements of the promoter region have now been well delineated functionally, while the proteins that interact with these elements are just beginning to be identified and their functional importance assessed.
C J, Kara, L H, Glimcher
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The evolution of MHC class II genes

Immunology Today, 1986
F, Figueroa, J, Klein
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Mhc Class II Genes of Nonhuman Primates

1997
In humans the HLA-D region was originally discovered by use of the mixed lymphocyte culture (MLC) test. This assay is based on coculturing lymphocyte suspensions of two unrelated individuals and actually measures the proliferative capacity of T lymphocytes.
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