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Prospective tumour mutation burden and neoantigen profiling predicts immunotherapy response in metastatic melanoma. [PDF]

NPJ Precis Oncol
Mao Y, Gide TN, Maher NG, Vignati D, Boutros A, Cornejo-Páramo P, Potter AJ, Carlino MS, Paver EC, Burke H, Menzies AM, Lo SN, da Silva IP, Scolyer RA, Long GV, Vergara IA, Wilmott JS.   +16 more
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Regulation of MHC class II gene expression by the class II transactivator

Nature Reviews Immunology, 2005
MHC class II molecules are pivotal for the adaptive immune system, because they guide the development and activation of CD4+ T helper cells. Fulfilling these functions requires that the genes encoding MHC class II molecules are transcribed according to a strict cell-type-specific and quantitatively modulated pattern.
Reith, Walter, LeibundGut-Landmann, Salomé, Waldburger, Jean-Marc   +2 more
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Transcriptional regulation of MHC class II genes

International Journal of Clinical & Laboratory Research, 1995
MHC class II molecules play a fundamental role in the homeostasis of the immune response, functioning as receptors for antigenic peptides to be presented to regulatory T cells. Both quantitative and qualitative alterations in the expression of these molecules on the cell surface dramatically affect the onset of the immune response, and may be the basis
SARTORIS, Silvia, R. S. Accolla
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Class II Mhc Genes in Rodent Evolution

Immunological Reviews, 1990
Article synthese sur l'evolution moleculaire des genes d'histocompatibilite de classe II chez les ...
F, Figueroa, J, Gutknecht, H, Tichy, J, Klein   +3 more
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Mutation of RFXAP, a Regulator of MHC Class II Genes, in Primary MHC Class II Deficiency

New England Journal of Medicine, 1997
Major-histocompatibility-complex (MHC) class II deficiency is an autosomal recessive primary immunodeficiency disease in which MHC class II molecules are absent. It is a genetically heterogeneous disease of gene regulation resulting from defects in several transactivating genes that regulate the expression of MHC class II genes.
Villard, Jean, Lisowska-Grospierre, B., van den Elsen, P., Fischer, A., Reith, Walter, Mach, Bernard   +5 more
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Transcriptional Regulation of MHC Class II Gene Expression: Are MHC Class II Genes Coordinately Regulated?

1990
MHC (Major Histocompatibility Complex) Class II antigens are polymorphic cell surface glycoproteins which bind foreign antigens and form a complex which is recognized by T lymphocyte antigen receptors. Presentation of foreign antigens by self MHC molecules to T cells triggers antigen-specific responses in the immune system.
H.-C. Liou, L. B. Ivashkiv, C. J. Kara, L. H. Glimcher   +3 more
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Immunosenescence of macrophages: reduced MHC class II gene expression

Experimental Gerontology, 2002
In order to determine the effect of aging on macrophages, we produced bone marrow-derived macrophages in vitro from young and aged mice. We analyzed the effect of aging on the genomic expression of macrophages in these conditions, without the influence of other cell types that may be affected by aging.
Carmen, Herrero, Carlos, Sebastián, Laura, Marqués, Mònica, Comalada, Jordi, Xaus, Annabel F, Valledor, Jorge, Lloberas, Antonio, Celada   +7 more
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MHC Class II and Related Genes

2008
Abstract The MHC class II antigen-processing pathway plays a central role in the adaptive immune response to microbial pathogens as the mechanism through which ligands are generated for recognition by CD4+ helper T cells. CD4+ helper T cells are activated by recognition of short peptide antigens stably bound to MHC class II molecules ...
Janet M McNicholl, Peter E Jensen, Jeremy M Boss   +2 more
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REGULATION OF MHC CLASS II GENES: Lessons from a Disease

Annual Review of Immunology, 1996
▪ Abstract  Precise regulation of major histocompatibility complex class II (MHC-II) gene expression plays a crucial role in the control of the immune response. A major breakthrough in the elucidation of the molecular mechanisms involved in MHC-II regulation has recently come from the study of patients that suffer from a primary immunodeficiency ...
Mach, Bernard, Steimle, Viktor, Martinez-Soria, Eduardo, Reith, Walter   +3 more
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