Results 261 to 270 of about 162,844 (305)

Regulation of transcription of MHC class II genes

Current Opinion in Immunology, 1997
Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II ...
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The class II genes of the rat MHC.

The Journal of Immunology, 1989
Abstract Genes that encode class II Ag from the MHC of the rat, the RT1 region, have been isolated as a series of cosmid clones. The cosmids define two clusters, each of which contains three identifiable sequences; one homologous to alpha-chain and two to beta-chain genes.
A G, Diamond, L E, Hood, J C, Howard, M, Windle, A, Winoto   +4 more
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Combined immunodeficiency with abnormal expression of MHC class II genes

Clinical Immunology and Immunopathology, 1989
The MHC class II CID represents an example of immunodeficiency in which the defect in expression of membrane glycoproteins leads to abnormal cell to cell interactions and thus to abnormal immune responses. It represents an interesting model which confirms the importance of MHC molecules in all immune responses to foreign antigens.
C, Griscelli, B, Lisowska-Grospierre, F, Le Deist, A, Durandy, A, Marcadet, A, Fischer, C, de Preval, B, Mach   +7 more
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Functional significance of polymorphism among MHC class II gene promoters

Tissue Antigens, 1996
The functional significance of polymorphism among MHC class II promoters in man and mouse is here reviewed, mainly in terms of the hypothesis of differential expression. The hypothesis proposes that differences between antigen‐presenting cells in MHC class II expression exert a co‐dominant effect on the Th1 ‐ Th2 cytokine balance, such that class II ...
GUARDIOLA J., MAFFEI A., LAUSTER R., MITCHISON N. A., ACCOLLA R. S., SARTORIS, Silvia   +5 more
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Negative regulation of MHC class II gene expression by CXCR4

Experimental Hematology, 2006
CXCR4 is overexpressed in 23 types of cancers of both hematopoietic and nonhematopoietic origin. Based on the known role of CXCR4 and its ligand CXCL12 in homing of hematopoietic cells, CXCR4 is likely to play a role in metastasis. We have initiated a study aimed at dissecting additional functions of CXCR4 in cancer cells, particularly in relation to ...
Carol, Sheridan, Miral, Sadaria, Poornima, Bhat-Nakshatri, Robert, Goulet, Howard J, Edenberg, Brian P, McCarthy, Cheong-Hee, Chang, Edward F, Srour, Harikrishna, Nakshatri   +8 more
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Functional expression of a transfected murine class II MHC gene

Nature, 1983
The activation of T helper lymphocytes involves the recognition of class II major histocompatibility complex antigens, which are dimeric glycoproteins (of subunit composition A alpha A beta or E alpha E beta) expressed on the surfaces of macrophages and B lymphocytes.
R N, Germain, M A, Norcross, D H, Margulies   +2 more
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Ancestral polymorphisms of MHC class II genes: Divergent allele advantage

Immunologic Research, 1990
獸醫學系暨研究所 ; 獸醫專業學院 ...
Wakeland, E. K., Boehme, S., She, J. X., Lu, C. C., Mcindoe, R. A., Ye, Y., Potts, W. K., Cheng, Ivan-Chen   +7 more
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Regulation of MHC class II gene transcription.

Current opinion in immunology, 1991
The transcriptional regulation of MHC class II genes involves the interaction of DNA-binding proteins with specific DNA sequences. The cis elements of the promoter region have now been well delineated functionally, while the proteins that interact with these elements are just beginning to be identified and their functional importance assessed.
C J, Kara, L H, Glimcher
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MHC class II A genes in the channel catfish (Ictalurus punctatus)

Developmental & Comparative Immunology, 1997
Two different cDNA sequences for major histocompatibility complex (MHC) class II beta chains from the channel catfish (Ictalurus punctatus) have been identified. Homology between these sequences and those previously identified as MHC class II B genes in other teleosts suggests they represent alleles of the DAB locus.
U B, Godwin, M, Flores, S, Quiniou, M R, Wilson, N W, Miller, L W, Clem, T J, McConnell   +6 more
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Polimorphism of bovine MHC class II genes

1994
Polymorphism of the bovine DRB, DQA, DQB, DYA, DOB and DIB genes was investigated using restriction fragment length polymorphism (RFLP) analysis, isoelectric focusing (IEF), class II serology and polymerase chain reaction (PCR) based typing techniques. The simultaneous application of multiple typing techniques and the characterization of multiple genes
C. J. Davies, I. Joosten, L. Andersson, M. A. Arriens, D. Bernoco, B. Bissumbhar, G. Byrns, M. J. T. van Eijk, B. Kristensen, H. A. Lewin, S. Mikko, A. L. G. Morgan, N. E. Muggli Cockett, P. R. Nilsson, R. A. Oliver, C. A. Park, J. J. Van Der Poel, M. Polli, R. L. Spooner, J. A. Stewart   +19 more
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