Pathophysiology of Alopecia Areata in the Pediatric Patient. [PDF]
Pediatr DermatolFitzhugh MH +3 more
europepmc +1 more source
Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments
Med Research, EarlyView.ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li +13 more
wiley +1 more source
Clinical settings in which human leukocyte antigen typing is still useful in the diagnosis of celiac disease. [PDF]
World J GastroenterolSchirru E +6 more
europepmc +1 more source
α‐Synuclein in Parkinson's Disease: From Bench to Bedside
Medicinal Research Reviews, Volume 45, Issue 3, Page 909-946, May 2025.ABSTRACT α‐Synuclein (α‐syn), a pathological hallmark of PD, is emerging as a bridging element at the crossroads between neuro/immune‐inflammatory responses and neurodegeneration in PD. Several evidence show that pathological α‐syn accumulates in neuronal and non‐neuronal cells (i.e., neurons, microglia, macrophages, skin cells, and intestinal cells ...
Gabriele Bellini +8 more
wiley +1 more source
Four Target Resequencing for the Bovine Major Histocompatibility Complex Region. Proof of Concept. [PDF]
HLAGiovambattista G +7 more
europepmc +1 more source
Molecular Nutrition &Food Research, EarlyView.In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang +7 more
wiley +1 more source
Epstein-Barr Infection, Hodgkin's Lymphoma, and the Immune System: Insights into the Molecular Mechanisms Facilitating Immune Evasion. [PDF]
Cancers (Basel)Tsotridou E, Hatzipantelis E.
europepmc +1 more source
The Role of Repeat Skeletal Muscle Biopsy: Indications, Yield and Outcomes
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims Muscle biopsy performed to investigate weakness and/or pain may be nondiagnostic and prompt repeat biopsy. We determined the indications and yield of rebiopsy. Methods Patients who underwent > 1 muscle biopsy (South Australia, 2000–2023) were identified.
Thomas Khoo +4 more
wiley +1 more source
Single-cell RNA sequencing reveals immunological link between house dust mite allergy and childhood asthma. [PDF]
Sci RepZou L, Chen K, Hong X, Ye B.
europepmc +1 more source
Identification of PPFIA3 as a Potential Prognostic and Immune Biomarker Through Pan‐Cancer Analysis
Organ Medicine, EarlyView.This study reveals a significant increase in the expression of PPFIA3 across various cancers, which is associated with poor prognosis. Notably, in patients receiving anti‐PD‐L1 treatment, high PPFIA3 expression is closely linked to improved survival rates and favorable prognosis, suggesting its potential as a predictive factor for immune checkpoint ...
Xianghong Wang +4 more
wiley +1 more source