Results 281 to 290 of about 224,267 (330)
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Regulation of MHC class II genes: lessons from a disease.
Annual Review of Immunology, 1996▪ Abstract Precise regulation of major histocompatibility complex class II (MHC-II) gene expression plays a crucial role in the control of the immune response. A major breakthrough in the elucidation of the molecular mechanisms involved in MHC-II regulation has recently come from the study of patients that suffer from a primary immunodeficiency ...
B. Mach +3 more
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Regulation of transcription of MHC class II genes.
Current Opinion in Immunology, 1997Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II ...
J. Boss
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Transcriptional regulation of MHC class II genes
International Journal of Clinical & Laboratory Research, 1995MHC class II molecules play a fundamental role in the homeostasis of the immune response, functioning as receptors for antigenic peptides to be presented to regulatory T cells. Both quantitative and qualitative alterations in the expression of these molecules on the cell surface dramatically affect the onset of the immune response, and may be the basis
SARTORIS, Silvia, R. S. Accolla
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Class II Mhc Genes in Rodent Evolution
Immunological Reviews, 1990Article synthese sur l'evolution moleculaire des genes d'histocompatibilite de classe II chez les ...
F, Figueroa +3 more
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Regulation of MHC class II gene expression by the class II transactivator
Nature Reviews Immunology, 2005MHC class II molecules are pivotal for the adaptive immune system, because they guide the development and activation of CD4+ T helper cells. Fulfilling these functions requires that the genes encoding MHC class II molecules are transcribed according to a strict cell-type-specific and quantitatively modulated pattern.
Reith, Walter +2 more
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1990
MHC (Major Histocompatibility Complex) Class II antigens are polymorphic cell surface glycoproteins which bind foreign antigens and form a complex which is recognized by T lymphocyte antigen receptors. Presentation of foreign antigens by self MHC molecules to T cells triggers antigen-specific responses in the immune system.
H.-C. Liou +3 more
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MHC (Major Histocompatibility Complex) Class II antigens are polymorphic cell surface glycoproteins which bind foreign antigens and form a complex which is recognized by T lymphocyte antigen receptors. Presentation of foreign antigens by self MHC molecules to T cells triggers antigen-specific responses in the immune system.
H.-C. Liou +3 more
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Immunosenescence of macrophages: reduced MHC class II gene expression
Experimental Gerontology, 2002In order to determine the effect of aging on macrophages, we produced bone marrow-derived macrophages in vitro from young and aged mice. We analyzed the effect of aging on the genomic expression of macrophages in these conditions, without the influence of other cell types that may be affected by aging.
Carmen, Herrero +7 more
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Ancestral polymorphisms of MHC class II genes: Divergent allele advantage
Immunologic Research, 1990獸醫學系暨研究所 ; 獸醫專業學院 ...
E. Wakeland +7 more
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MHC Class II and Related Genes
2008Abstract The MHC class II antigen-processing pathway plays a central role in the adaptive immune response to microbial pathogens as the mechanism through which ligands are generated for recognition by CD4+ helper T cells. CD4+ helper T cells are activated by recognition of short peptide antigens stably bound to MHC class II molecules ...
Janet M McNicholl +2 more
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The class II genes of the rat MHC.
The Journal of Immunology, 1989Abstract Genes that encode class II Ag from the MHC of the rat, the RT1 region, have been isolated as a series of cosmid clones. The cosmids define two clusters, each of which contains three identifiable sequences; one homologous to alpha-chain and two to beta-chain genes.
A G, Diamond +4 more
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