Results 291 to 300 of about 520,866 (339)

Regulation of transcription of MHC class II genes

Current Opinion in Immunology, 1997
Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II ...
J. Boss
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MHC class II genes in European wolves: a comparison with dogs

Immunogenetics, 2002
The genome of the grey wolf, one of the most widely distributed land mammal species, has been subjected to both stochastic factors, including biogeographical subdivision and population fragmentation, and strong selection during the domestication of the dog.
Seddon, JM, Ellegren, H
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Regulation of MHC class II gene expression by the class II transactivator [PDF]

Nature Reviews Immunology, 2005
MHC class II molecules are pivotal for the adaptive immune system, because they guide the development and activation of CD4+ T helper cells. Fulfilling these functions requires that the genes encoding MHC class II molecules are transcribed according to a strict cell-type-specific and quantitatively modulated pattern.
Salomé LeibundGut-Landmann, Salomé LeibundGut-Landmann, Jean-Marc Waldburger, Walter Reith   +3 more
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Transcriptional regulation of MHC class II genes

International Journal of Clinical & Laboratory Research, 1995
MHC class II molecules play a fundamental role in the homeostasis of the immune response, functioning as receptors for antigenic peptides to be presented to regulatory T cells. Both quantitative and qualitative alterations in the expression of these molecules on the cell surface dramatically affect the onset of the immune response, and may be the basis
SARTORIS, Silvia, R. S. Accolla
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The class II genes of the rat MHC.

The Journal of Immunology, 1989
Abstract Genes that encode class II Ag from the MHC of the rat, the RT1 region, have been isolated as a series of cosmid clones. The cosmids define two clusters, each of which contains three identifiable sequences; one homologous to alpha-chain and two to beta-chain genes.
A G, Diamond, L E, Hood, J C, Howard, M, Windle, A, Winoto   +4 more
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Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.

Genomics, 1994
Cosmid walking of about 250 kb from MHC class III gene CYP21 to class II was conducted. The gene for receptor of advanced glycosylation end products of proteins (RAGE, a member of immunoglobulin superfamily molecules), the PBX2 homeobox gene designated ...
Kimihiko Sugaya, Tatsuo Fukagawa, Ken-ichi Matsumoto, Kazuei Mita, Ei-ichi Takahashi, Asako Ando, H. Inoko, Toshimichi Ikemura   +7 more
semanticscholar   +1 more source

Class II Mhc Genes in Rodent Evolution

Immunological Reviews, 1990
Article synthese sur l'evolution moleculaire des genes d'histocompatibilite de classe II chez les ...
Jutta Gutknecht, Felipe Figueroa, Jan Klein, Jan Klein, Herbert Tichy   +4 more
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In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome.

Science, 1991
Major histocompatibility complex (MHC) class II genes are coordinately regulated and show tissue-specific expression. With the use of in vivo footprinting, common promoter sites in these genes were found to be occupied only in cells that expressed the ...
C. Kara, L. Glimcher
semanticscholar   +1 more source

Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen.

Science, 1999
In an effort to identify tumor-specific antigens recognized by CD4(+) T cells, an approach was developed that allows the screening of an invariant chain-complementary DNA fusion library in a genetically engineered cell line expressing the essential ...
Rongfu Wang, Xiang Wang, Alicia C. Atwood, S. Topalian, Steven A. Rosenberg   +4 more
semanticscholar   +1 more source

The enhancer in an MHC class II gene, in vitro and in mouso

Biochimie, 1988
The E alpha class II gene of the major histocompatibility complex is expressed in a variety of immunocompetent cells. Part of the control of tissue-specific expression is mediated by a block of sequences found far upstream of the transcriptional startsite; this stretch is necessary for expression in the B lymphocytes of transgenic mice, but largely ...
Christophe Benoist, A Dorn, Philippe Gerber, Jorg Fehling, Gabrielle Lang, Caroline Waltzinger, Diane Mathis, Gérard Garcin, W Koch   +8 more
openaire   +3 more sources