Results 291 to 300 of about 224,267 (330)

Combined immunodeficiency with abnormal expression of MHC class II genes

Clinical Immunology and Immunopathology, 1989
The MHC class II CID represents an example of immunodeficiency in which the defect in expression of membrane glycoproteins leads to abnormal cell to cell interactions and thus to abnormal immune responses. It represents an interesting model which confirms the importance of MHC molecules in all immune responses to foreign antigens.
C, Griscelli, B, Lisowska-Grospierre, F, Le Deist, A, Durandy, A, Marcadet, A, Fischer, C, de Preval, B, Mach   +7 more
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Functional significance of polymorphism among MHC class II gene promoters

Tissue Antigens, 1996
The functional significance of polymorphism among MHC class II promoters in man and mouse is here reviewed, mainly in terms of the hypothesis of differential expression. The hypothesis proposes that differences between antigen‐presenting cells in MHC class II expression exert a co‐dominant effect on the Th1 ‐ Th2 cytokine balance, such that class II ...
GUARDIOLA J., MAFFEI A., LAUSTER R., MITCHISON N. A., ACCOLLA R. S., SARTORIS, Silvia   +5 more
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Negative regulation of MHC class II gene expression by CXCR4

Experimental Hematology, 2006
CXCR4 is overexpressed in 23 types of cancers of both hematopoietic and nonhematopoietic origin. Based on the known role of CXCR4 and its ligand CXCL12 in homing of hematopoietic cells, CXCR4 is likely to play a role in metastasis. We have initiated a study aimed at dissecting additional functions of CXCR4 in cancer cells, particularly in relation to ...
Carol, Sheridan, Miral, Sadaria, Poornima, Bhat-Nakshatri, Robert, Goulet, Howard J, Edenberg, Brian P, McCarthy, Cheong-Hee, Chang, Edward F, Srour, Harikrishna, Nakshatri   +8 more
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Functional expression of a transfected murine class II MHC gene

Nature, 1983
The activation of T helper lymphocytes involves the recognition of class II major histocompatibility complex antigens, which are dimeric glycoproteins (of subunit composition A alpha A beta or E alpha E beta) expressed on the surfaces of macrophages and B lymphocytes.
R N, Germain, M A, Norcross, D H, Margulies   +2 more
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Regulation of MHC class II gene transcription.

Current opinion in immunology, 1991
The transcriptional regulation of MHC class II genes involves the interaction of DNA-binding proteins with specific DNA sequences. The cis elements of the promoter region have now been well delineated functionally, while the proteins that interact with these elements are just beginning to be identified and their functional importance assessed.
C J, Kara, L H, Glimcher
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MHC class II A genes in the channel catfish (Ictalurus punctatus)

Developmental & Comparative Immunology, 1997
Two different cDNA sequences for major histocompatibility complex (MHC) class II beta chains from the channel catfish (Ictalurus punctatus) have been identified. Homology between these sequences and those previously identified as MHC class II B genes in other teleosts suggests they represent alleles of the DAB locus.
U B, Godwin, M, Flores, S, Quiniou, M R, Wilson, N W, Miller, L W, Clem, T J, McConnell   +6 more
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Polimorphism of bovine MHC class II genes

1994
Polymorphism of the bovine DRB, DQA, DQB, DYA, DOB and DIB genes was investigated using restriction fragment length polymorphism (RFLP) analysis, isoelectric focusing (IEF), class II serology and polymerase chain reaction (PCR) based typing techniques. The simultaneous application of multiple typing techniques and the characterization of multiple genes
C. J. Davies, I. Joosten, L. Andersson, M. A. Arriens, D. Bernoco, B. Bissumbhar, G. Byrns, M. J. T. van Eijk, B. Kristensen, H. A. Lewin, S. Mikko, A. L. G. Morgan, N. E. Muggli Cockett, P. R. Nilsson, R. A. Oliver, C. A. Park, J. J. Van Der Poel, M. Polli, R. L. Spooner, J. A. Stewart   +19 more
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The MHC class I genes of the rhesus monkey. Different evolutionary histories of MHC class I and II genes in primates

The Journal of Immunology, 1996
Abstract Homologues of the human HLA-A and -B MHC class I loci have been found in great apes and Old World primates suggesting that these two loci have existed for at least 30 million years. The C locus, however, shows some sequence similarity to the B locus and has been found only in gorillas, chimpanzees, and humans.
J E, Boyson, C, Shufflebotham, L F, Cadavid, J A, Urvater, L A, Knapp, A L, Hughes, D I, Watkins   +6 more
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A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes

Nature, 1985
Class II (or Ia) antigens are highly polymorphic surface molecules which are essential for the cellular interactions involved in the immune response. In man, these antigens are encoded by a complex multigene family which is located in the major histocompatibility complex (MHC) and which comprises up to 12 distinct alpha- and beta-chain genes, coding ...
C, de Préval, B, Lisowska-Grospierre, M, Loche, C, Griscelli, B, Mach   +4 more
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New class ll-like genes in the murine MHC

Nature, 1991
Major histocompatibility complex (MHC) class I molecules present endogenous antigens to CD8+ (cytotoxic) T cells. MHC class II molecules present primarily exogenously derived antigens to CD4+ T cells. Three new genes (Ma, Mb1 and Mb2) located between the Pb and Ob genes of the murine MHC have properties indicating that they are members of the MHC class
S G, Cho, M, Attaya, J J, Monaco
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