Results 61 to 70 of about 224,267 (330)

Association between NDO-LID and PGL-1 for leprosy and class I and II human leukocyte antigen alleles in an indigenous community in Southwest Amazon

Brazilian Journal of Infectious Diseases, 2020
The frequencies of the Human leukocyte antigen (HLA) alleles in the Puyanawa indigenous reserve population and their association with the NDO-LID and ELISA PGL-1 rapid serological test was assessed.
Stéfanie Ferreira Teles, Eliane Aparecida Silva, Rodrigo Medeiros de Souza, Jane Tomimori, Marcos Cesar Florian, Rogério Oliveira Souza, Elaine Valim Camarinha Marcos, Fabiana Covolo de Souza-Santana, Mônica Antar Gamba   +8 more
doaj   +1 more source

Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning. [PDF]

, 1995
Identifying the immunogenic proteins that elicit pathogen-specific T cell responses is key to rational vaccine design. While several approaches have succeeded in identifying major histocompatibility complex (MHC) class I bound peptides that stimulate CD8+
Campbell, D, Sanderson, S, SHASTRI, Nilabh   +2 more
core   +1 more source

Digital gene expression analysis of the zebra finch genome [PDF]

, 2010
Background: In order to understand patterns of adaptation and molecular evolution it is important to quantify both variation in gene expression and nucleotide sequence divergence.
Balakrishnan, C.N., Burke, T., Ekblom, R., Slate , J.   +3 more
core   +4 more sources

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

bioRxiv, 2022
CD4+ T cells orchestrate the adaptive immune response against pathogens and cancer by recognizing epitopes presented on MHC-II molecules. The high polymorphism of MHC-II genes represents an important hurdle towards accurate prediction and identification ...
Julien Racle, P. Guillaume, J. Schmidt, Justine Michaux, A. Larabi, K. Lau, Marta A. S. Perez, Giancarlo Croce, Raphael Genolet, G. Coukos, V. Zoete, F. Pojer, M. Bassani-Sternberg, A. Harari, D. Gfeller   +14 more
semanticscholar   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.

PLoS Biology, 2006
The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used the Monodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex
Katherine Belov, Janine E Deakin, Anthony T Papenfuss, Michelle L Baker, Sandra D Melman, Hannah V Siddle, Nicolas Gouin, David L Goode, Tobias J Sargeant, Mark D Robinson, Matthew J Wakefield, Shaun Mahony, Joseph G R Cross, Panayiotis V Benos, Paul B Samollow, Terence P Speed, Jennifer A Marshall Graves, Robert D Miller   +17 more
doaj   +1 more source

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Cell Reports, 2023
Summary: Disruption of antigen presentation via loss of major histocompatibility complex (MHC) expression is a strategy whereby cancer cells escape immune surveillance and develop resistance to immunotherapy.
Michael B. Mumphrey, Noshad Hosseini, Abhijit Parolia, Jie Geng, Weiping Zou, Malini Raghavan, Arul Chinnaiyan, Marcin Cieslik   +7 more
doaj   +1 more source

MHC-linked and un-linked class I genes in the wallaby [PDF]

, 2009
Background: MHC class I antigens are encoded by a rapidly evolving gene family comprising classical and non-classical genes that are found in all vertebrates and involved in diverse immune functions.
Beck, S., Belov, K., Cheng, Y., Coggill, P., Deakin, J.E., Harrow, J., Hart, E., Siddle, H.V., Wong, E.S.W.   +8 more
core   +4 more sources

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source