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Historical Perspectives of myc Gene Studies
1995Much of our current understanding of cancer genes originated from classical studies of avian tumors. The very first documented observation by Rous in 1910 suggested that certain avian sarcomas could be transmitted by a filterable infectious agent.1–4 Subsequently, isolates of the infectious agents were recognized under the electron microscope as ...
Chi V. Dang, Linda A. Lee
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Downstream Regulatory Elements in the c-myc Gene
1990Deregulated expression of the c-myc gene appears to play an important role in the development of Burkitt’s lymphoma (BL) and certain other lymphoid tumors. Physiologic regulation of the c-myc gene is complicated, involving the interplay of distinct transcriptional and post transcriptional mechanisms.
M, Zajac-Kaye, B, Yu, N, Ben-Baruch
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Anticancer research, 1989
Human c-myc and normal or mutant T24 H-ras1 genes either linked to the regulatory sequences of the human metallothionein IIa gene or unlinked have been employed individually or in combination to transfect early passage Chinese hamster lung cells.
Spandidos, Demetrios A., Lang, J. C.
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Human c-myc and normal or mutant T24 H-ras1 genes either linked to the regulatory sequences of the human metallothionein IIa gene or unlinked have been employed individually or in combination to transfect early passage Chinese hamster lung cells.
Spandidos, Demetrios A., Lang, J. C.
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[Apoptosis induced by myc family genes].
Nihon rinsho. Japanese journal of clinical medicine, 1996Recent studies have revealed that c-Myc is involved not only in cellular transformation but also in apoptosis induction. However, the intronless myc family genes such as s-myc, N-myc2, mycL2 lack transforming ability and retain only apoptosis inducing activity.
S, Kagaya, C, Kitanaka, Y, Kuchino
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N-myc Gene Amplification in Teratoma
JNCI Journal of the National Cancer Institute, 1990I, Ishiwata +8 more
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[A study of amplifications of myc gene (c-myc and N-myc) in human ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi, 1990Amplifications of myc oncogenes (c-myc, N-myc) were studied by Southern blot hybridization methods in ovarian cancers. Fourteen cases were primary ovarian cancers and one case was metastatic ovarian cancer. Primary and metastatic foci of three primary ovarian cancers were compared.
A, Kataoka, M, Yakushiji, M, Kojiro
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