Results 181 to 190 of about 26,095 (198)
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Biochemical and biological comparison of HIV-1 NEF and ras gene products
Virology, 1991Human immunodeficiency virus type 1 (HIV-1) NEF protein has been reported to share certain biochemical and structural properties with known oncoproteins like src or rats. To determine whether this is a general property of NEF from various HIV isolates, three different NEF proteins were expressed in Escherichia coli using a thermoinducible expression ...
A R, Nebreda +5 more
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One explanation of Nef gene behavior
Medical Hypotheses, 1999The Nef (negative factor) gene of primate retroviruses may serve an important evolutionary function. Selection pressures in the natural world, may at times, demand that retroviral infection not cause disease in a newly entered host species. Genetic alterations in the Nef gene may function to permit retroviral speciation by lowering retroviral ...
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The HIV-1 nef gene acts as a positive viral infectivity factor
Trends in Microbiology, 1994The gene product of the nef gene of HIV-1 acts both to increase the infectivity of viral particles and to reduce the expression of the CD4 receptor molecule on the cell surface. These two functions of Nef may be related, in that downregulation of CD4 may promote the production of HIV that has greater infectivity.
M D, Miller, M B, Feinberg, W C, Greene
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Functional Analysis of the vpx, vpr, and nef Genes of Simian Immunodeficiency Virus
Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology, 1995The role of the vpx, vpr, and nef genes in the replication of simian immunodeficiency virus (SIV) was investigated using point and deletion mutations in these genes. The effects on replication kinetics of single or combined mutants--vpx, vpr, vpx-vpr, vpx-nef, vpr-nef, and vpx-vpr-nef--in established lymphoid CEMx174 and MT-4 cells were negligible ...
I W, Park, J, Sodroski
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Characterization and signature pattern analysis of Korean clade HIV-1 using nef gene sequences
The Journal of Microbiology, 2008Phylogenetic studies of the HIV-1 gene sequences isolated from Korean patients have suggested that most of Korean isolates belong to the subtype B strain. This study aims to characterize the Korean clade by molecular phylogenetic analysis using all of the Korean nef gene sequences registered in the NCBI GenBank (N=422), in addition to 41 reference ...
Chan Seung, Park +3 more
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Intrahost and Interhost Variability of the HIV Type 1nefGene in Brazilian Children
AIDS Research and Human Retroviruses, 2009Many aspects of HIV-1 pathogenesis are affected by Nef protein activity, and efforts have been made to study variation in the nef gene and how that variation relates to disease outcome. We studied the genetic diversity of the nef gene in distinct clones obtained from the same patient (intrahost) and in sequences obtained from different hosts (interhost)
Cavalieri, Elizabeth UNIFESP +6 more
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Sequence Analysis of Neuroinvasive and Blood-Derived HIV-1 nef Genes
1995Neurological disease associated with acquired immune deficiency syndrome (AIDS) relates to the presence of human immunodeficiency virus-1 (HIV-1) in the central nervous system (CNS). In support, HIV-1, like other lentiviruses, invades the CNS and can be readily isolated from cerebrospinal fluid (CSF) and brain of HIV-infected individuals.
Ruth Brack-Werner +7 more
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Virus Research, 1998
To elucidate the function of nef, we constructed infectious chimeric clones between human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) of macaques, by deleting a part of the nef sequence from the HIV-1 genome and inserting the entire nef gene from the pathogenic molecular clone, SIVmac239.
K, Yoon, H W, Kestler, S, Kim
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To elucidate the function of nef, we constructed infectious chimeric clones between human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) of macaques, by deleting a part of the nef sequence from the HIV-1 genome and inserting the entire nef gene from the pathogenic molecular clone, SIVmac239.
K, Yoon, H W, Kestler, S, Kim
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The HIV-1 nef gene product is associated with phosphorylation of a 46 kD cellular protein
AIDS, 1992To study the biochemical properties of the HIV-1 nef gene product.Earlier reports suggested that Nef protein is phosphorylated and has kinase activity. These properties were examined using an in vitro translated product.A DNA fragment encoding Nef of HIV-1SF2 was transcribed in vitro under the control of T7 promoter.
L, Poulin, J A, Levy
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Control of human immunodeficiency virus replication by the tat, rev, nef and protease genes
Current Opinion in Immunology, 1991Immediately after infection, human immunodeficiency virus directs the synthesis of three regulatory proteins tat, rev and nef that together allow the synthesis of the structural proteins of the virus after a delay of several hours. Viral mRNA production is controlled by the tat gene, which appears to stimulate elongation by RNA polymerase II, and the ...
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