Results 141 to 150 of about 47,513 (307)

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours

The Journal of Pathology, EarlyView.
Abstract Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.
Iris D Nagtegaal, Elizabeth A Montgomery, Alexandros D Polydorides, Anthony J Gill, Motohiro Kojima, Mark J Arends   +5 more
wiley   +1 more source

Comparative Analysis of Homo sapiens and Mus musculus Cyclin-Dependent Kinase (CDK) Inhibitor Genes P16 (MTSl) and PIS (MTS2)

, 1995
Cyclin-dependent kinase inhibitors are a growing family of molecules that regulate important transitions in the cell cycle. At least one of these molecules, p16, has been implicated in human tumorigenesis while its close homolog, p15, is induced by cell ...
Stone, Steven, Wold, Barbara J., Wagner, Roger, Wang, Susan L., Kozak, Christine A., Kamb, Alexander, Jiang, Ping, Dayananth, Priya   +7 more
core  

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile

Biological Research, 2007
The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer.
LEDA M GUZMAN, CHIHAYA KORIYAMA, SUMINORI AKIBA, YOSHITO EIZURU, DARWINS CASTILLO, ALEJANDRO CORVALAN, FRANCISCO R AGUAYO   +6 more
doaj  

Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The aim of this study was to investigate the changes in Epac1 and ferroptosis‐related proteins in aged mice and the House Ear Institute‐Organ of Corti 1 (HEI‐OC1) cells, with the goal of elucidating their potential role in age‐related hearing loss. Methods The expression of Epac1 in the cochlea of C57BL/6J mice was examined by using
Wen‐Jun An, Chen‐Yu Xu, Meng‐Ya Shen, Xiao‐Tao Guo, Chun‐Chen Pan, Jing‐Wu Sun, Xiao‐Min Tang, Jia‐Qiang Sun   +7 more
wiley   +1 more source

Correlation between Methylation and Expression Level of P15 and P16 Genes during Differentiation of Cord Blood Stem Cells into Erythroid Lineage Mediated by Erythropoietin

Novelty in Biomedicine, 2015
Background: Several influential factors such as transcription factors and intracellular signaling components are involved in differentiation of stem cells into a specific lineage. P15 and p16 proteins are among these factors.
Mehdi Azad, Mehdi Goudarzi, Mehdi Sahmani, Ali Dehghanifard, Naser Mobarra, Mousa Vatanmakanian, Mohammad Hosein Moghaddasi, Fatemeh Skandari, Saeid Kaviani   +8 more
doaj  

p16/CDKN2 alterations and pRb expression in oesophageal squamous carcinoma.

, 1998
BACKGROUND: Upregulation of the cell cycle associated genes, p16/CDKN2 and the retinoblastoma susceptibility gene (Rb), is commonly seen during the proliferation of normal cells.
Ruol A, RUGGE, MASSIMO, Parenti AR, PLEBANI, MARIO, Baffa R, Busatto G, Shiao YH   +6 more
core   +1 more source

Role of p16 expression in head and neck carcinoma

, 2023
Protein p16, kodiran genom INK4A, pripada obitelji gena INK4 koja ima ulogu tumor supresora i negativno regulira signalni put pRb-E2F. Genetskim promjenama gena INK4A dolazi do potpune inaktivacije ili do smanjene funkcije proteina p16. Karcinomi glave i
Šimatović, Domagoj
core  

DNA‐Methylation for Risk‐Stratification of Women Without a Fully Visible Transformation Zone at Colposcopy: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the performance of DNA methylation markers for the detection of cervical precancer among screening‐positive older women without a fully visible transformation zone at colposcopy (TZ3). Design Cross‐sectional study. Setting Colposcopy clinics, Central Denmark Region, 2019–2021.
Karen Omann Binderup, Joachim Boers, Line Winther Gustafson, Berit Andersen, Lone Kjeld Petersen, Pinar Bor, Joost Gribnau, Wim G. V. Quint, Henk Van Den Munckhof, Mette Tranberg, Anne Hammer   +10 more
wiley   +1 more source